METHODS: All patients with histologically confirmed PanNET G2 who underwent successful surgery between 2006 and 2020 with the intention of radical treatment were enrolled.
RESULTS: In total, 44 patients were eligible for the analysis. The average follow-up was 8.39 ± 4.5 years. Disease recurrence was observed in 16 (36.36%) patients. The dominant location of the primary tumour was the tail of the pancreas (43.18%), especially in the subgroup with disease recurrence (56.25%). The smallest tumour diameter associated with the PanNET G2 recurrence was 22 mm. The relationship between the largest dimension of the tumour with a division of < 4 cm vs. > 4 cm and the relapse was close to statistical significance. Recurrence was associated with a larger tumour size (p = 0.018). There was a statistically significant relationship and a weak correlation between Ki-67 (p = 0.036, V Cramer = 0.371) and disease relapse.
CONCLUSIONS: For the group of PanNET G2 patients after radical surgery, the overall risk of recurrence was 36.36%, with the highest rate in the first 5 years after surgery, but in individual cases it occurred significantly later, even 10 years after surgery. The most important predictive factors of the PanNET G2 recurrence was Ki-67 over 5.75% and size of tumour > 4 cm.
方法:纳入所有经组织学证实的PanNETG2患者,这些患者在2006年至2020年之间成功接受了根治性治疗。
结果:总计,44名患者符合分析条件。平均随访8.39±4.5年。16例(36.36%)患者出现疾病复发。原发肿瘤的主要部位是胰尾(43.18%),尤其是在疾病复发的亚组(56.25%)。与PanNETG2复发相关的最小肿瘤直径为22mm。<4cm的肿瘤最大尺寸与之间的关系>4cm,复发接近统计学意义。复发与较大的肿瘤大小相关(p=0.018)。Ki-67(p=0.036,VCramer=0.371)与疾病复发之间存在统计学上的显着关系和弱相关性。
结论:对于根治性手术后的PanNETG2患者组,总体复发风险为36.36%,手术后的前5年发病率最高,但在个别情况下,它发生得很晚,甚至手术后10年。PanNETG2复发的最重要预测因素是Ki-67超过5.75%,肿瘤大小>4cm。