PDF(Pubmed)
Abstract：
UNASSIGNED: This case report demonstrates the possibility of successful eye and vision-sparing therapy for caruncular melanoma.
UNASSIGNED: We present an atypical presentation of a caruncular melanoma. After excisional biopsy, residual flat conjunctival melanosis resolved using topical chemotherapy (5-fluorouracil), which was well tolerated. Relapse of the melanoma was treated with external beam radiotherapy, but the tumor grew despite treatment. Eighteen months after complete excision of the relapsed melanoma, the patient remains tumor-free while the eye and its function remain preserved.
UNASSIGNED: This case report suggests that aggressive eye-sparing therapy for caruncular melanoma combining surgery, adjuvant topical chemotherapy, and external beam radiotherapy, can be an alternative for primary orbital exenteration.
UNASSIGNED: We present an atypical presentation of a caruncular melanoma. After excisional biopsy, residual flat conjunctival melanosis resolved using topical chemotherapy (5-fluorouracil), which was well tolerated. Relapse of the melanoma was treated with external beam radiotherapy, but the tumor grew despite treatment. Eighteen months after complete excision of the relapsed melanoma, the patient remains tumor-free while the eye and its function remain preserved.
UNASSIGNED: This case report suggests that aggressive eye-sparing therapy for caruncular melanoma combining surgery, adjuvant topical chemotherapy, and external beam radiotherapy, can be an alternative for primary orbital exenteration.
摘要：
■该病例报告证明了保留眼和视力的治疗成功的可能性。
■我们提出了一个不典型的表现，表现为环状黑色素瘤。切除活检后，使用局部化疗（5-氟尿嘧啶）解决残留的扁平结膜黑变病，这是很好的耐受性。黑色素瘤复发采用外束放射治疗，但是尽管经过治疗，肿瘤还是在增长。完全切除复发性黑色素瘤18个月后，患者仍然没有肿瘤，而眼睛及其功能仍然保留。
此病例报告表明，积极的保留眼睛的治疗联合手术治疗，辅助局部化疗，和外部束放射治疗，可以替代原发性眼眶切除术。
■我们提出了一个不典型的表现，表现为环状黑色素瘤。切除活检后，使用局部化疗（5-氟尿嘧啶）解决残留的扁平结膜黑变病，这是很好的耐受性。黑色素瘤复发采用外束放射治疗，但是尽管经过治疗，肿瘤还是在增长。完全切除复发性黑色素瘤18个月后，患者仍然没有肿瘤，而眼睛及其功能仍然保留。
此病例报告表明，积极的保留眼睛的治疗联合手术治疗，辅助局部化疗，和外部束放射治疗，可以替代原发性眼眶切除术。
