PDF(Pubmed)
Abstract：
In India, organophosphorus (OP) chemicals known as anticholinesterases cause a considerable amount of disease and mortality. While precise figures are unavailable, data from hospitals indicates that about 50% of acute poisoning episodes are attributed to organophosphates. Anticholinesterases, when accidentally or suicidally exposed, cause three different neurological disorders. The first is an acute cholinergic crisis that can be fatal and necessitates administration in an intensive care unit; the second is an intermediate syndrome that frequently results in cranial nerve palsies, proximal and respiratory muscle weakness, and respiratory support for patients; and the third is a delayed organophosphate-induced polyneuropathy. Together, these neurobehavioral alterations have been identified and are referred to as \"chronic organophosphate-induced neuropsychiatric disorders\" (COPIND). A 40-year-old male patient tried suicide by swallowing a significant dose of OP pesticide. He was breathing heavily, gasping for air, foaming at the lips, and smelled intensely of pesticide when he was brought to a private hospital. Investigations like nerve conduction velocity (NCV) were done, which revealed motor axonal polyneuropathy.
摘要：
在印度,称为抗胆碱酯酶的有机磷（OP）化学物质会导致大量疾病和死亡。虽然没有确切的数字，来自医院的数据表明，约50％的急性中毒事件归因于有机磷。抗胆碱酯酶，当意外或自杀暴露时，导致三种不同的神经系统疾病。第一种是急性胆碱能危象，可能是致命的，需要在重症监护病房给药；第二种是中间综合征，经常导致颅神经麻痹，近端和呼吸肌无力，和患者的呼吸支持;第三是迟发性有机磷引起的多发性神经病。一起,这些神经行为改变已被确认,被称为"慢性有机磷引起的神经精神障碍"(COPIND).一名40岁的男性患者试图通过吞咽大量OP杀虫剂来自杀。他呼吸沉重，喘气的空气，嘴唇起泡，当他被带到一家私人医院时，他闻到了强烈的农药味。进行了神经传导速度（NCV）等调查，显示了运动性轴索多发性神经病。
