PDF(Pubmed)
Abstract：
Azithromycin, an azolide antibiotic with structural and functional similarities to macrolides, possesses distinct features such as its effects persisting for seven days, an extended half-life by administering it once daily for three days, and strong antimicrobial activity. Notably, vomiting and diarrhea are recognized as the primary adverse events related to azithromycin. In this particular case, we present a unique case describing a purpuric-type drug eruption associated with azithromycin, which represents an uncommon cutaneous manifestation. A 64-year-old female developed a purpuric eruption on her trunk and lower extremities seven days after receiving daily intravenous azithromycin for upper bronchitis. A previous occurrence of punctate purpuric eruption following azithromycin administration was documented in her medical history. The diagnosis of azithromycin-induced skin eruption was confirmed based on the clinical progression and the recurrence of the eruption upon re-administration of the drug. In response to this diagnosis, the patient underwent treatment involving the discontinuation of azithromycin and the application of topical betamethasone butyrate propionate ointment. Remarkably, her eruption significantly improved within two weeks, although residual pigmentation persisted post-treatment. Additionally, we offer a comprehensive review of the literature, examining cases of drug eruptions related to azithromycin.
摘要：
阿奇霉素,一种与大环内酯类结构和功能相似的唑类抗生素，具有独特的特征，例如其效果持续七天，每天给药一次，持续三天，延长了半衰期，和强大的抗菌活性。值得注意的是,呕吐和腹泻被认为是与阿奇霉素相关的主要不良事件.在这种特殊情况下，我们提出了一个独特的案例，描述了与阿奇霉素相关的紫癜型药疹，这代表了一种不常见的皮肤表现。一名64岁的女性在每天静脉注射阿奇霉素治疗上支气管炎7天后，躯干和下肢出现紫癜性皮疹。在她的病史中记录了阿奇霉素给药后的点状紫癜性爆发。根据临床进展和再次给药时的复发，确认了阿奇霉素引起的皮肤喷发的诊断。为了回应这个诊断，患者接受了停药阿奇霉素和局部应用丁酸倍他米松软膏的治疗.值得注意的是,她的喷发在两周内显着改善，尽管治疗后仍存在残留的色素沉着。此外,我们对文献进行了全面的回顾，检查与阿奇霉素有关的药疹病例。
