PDF(Pubmed)
Abstract：
Squamous cell carcinoma is the most predominant type of malignancy in the head and neck region with neuroendocrine carcinomas (NECs) being a rare occurrence. Here we report a rare case of small cell non-keratinizing NEC (WHO grade 3), TNM (tumor, node, and metastasis) stage T3N1M0, involving the larynx and the base of the tongue, in a 54-year-old male patient, demonstrating its rarity in an uncommon anatomical site and an aggressive and relatively uncommon pattern of spread for this tumor, over a period of two months. NECs in the head and neck region, especially those affecting the larynx and the posterior third of the tongue, remain exceedingly rare, comprising only a small fraction of malignancies in this region. The aggressive nature and distinct pattern of spread observed in this case underscore the importance of recognizing such unusual presentations for appropriate diagnosis and management. Given the rarity of this tumor type, a comprehensive understanding of its clinicopathological features is essential for guiding effective treatment strategies. We also discuss the treatment.
摘要：
鳞状细胞癌是头颈部最主要的恶性肿瘤，神经内分泌癌（NECs）很少见。在这里，我们报告了一个罕见的小细胞非角化NEC病例（WHO3级），TNM（肿瘤，节点,和转移）阶段T3N1M0，涉及喉和舌根，一名54岁的男性患者,证明了它在一个不常见的解剖部位的罕见性，以及这种肿瘤的侵袭性和相对不常见的扩散模式，在两个月的时间里。头部和颈部区域的NEC，尤其是那些影响喉部和舌后三分之一的人，仍然非常罕见，仅包含该地区一小部分恶性肿瘤。在这种情况下观察到的侵略性和独特的传播模式强调了识别这种异常表现对于适当诊断和管理的重要性。鉴于这种肿瘤类型的罕见，全面了解其临床病理特征对于指导有效的治疗策略至关重要.我们也讨论了治疗。
