PDF(Pubmed)
Abstract：
Successful pregnancy requires the tolerance of the maternal immune system for the semi-allogeneic embryo, as well as a synchrony between the receptive endometrium and the competent embryo. The annexin family belongs to calcium-regulated phospholipid-binding protein, which functions as a membrane skeleton to stabilize the lipid bilayer and participate in various biological processes in humans. There is an abundance of the annexin family at the maternal-fetal interface, and it exerts a crucial role in embryo implantation and the subsequent development of the placenta. Altered expression of the annexin family and dysfunction of annexin proteins or polymorphisms of the ANXA gene are involved in a range of pregnancy complications. In this review, we summarize the current knowledge of the annexin A protein family at the maternal-fetal interface and its association with female reproductive disorders, suggesting the use of ANXA as the potential therapeutic target in the clinical diagnosis and treatment of pregnancy complications.
摘要：
成功的怀孕需要母体免疫系统对半同种异体胚胎的耐受性，以及接受性子宫内膜和感受态胚胎之间的同步性。膜联蛋白家族属于钙调节磷脂结合蛋白，其作为膜骨架稳定脂质双层并参与人类的各种生物过程。在母胎界面上有大量的膜联蛋白家族，它在胚胎植入和随后的胎盘发育中起着至关重要的作用。膜联蛋白家族的表达改变和膜联蛋白的功能障碍或ANXA基因的多态性与一系列妊娠并发症有关。在这次审查中,我们总结了母胎界面膜联蛋白A家族的最新知识及其与女性生殖障碍的关系，提示在妊娠并发症的临床诊断和治疗中使用ANXA作为潜在的治疗靶点。
