Abstract:
Lactic acidosis is commonly associated with tissue hypoperfusion and gives rise to concern regarding hypoxia or underlying hypotension. In the cancer patient, especially one undergoing chemotherapy, there is always concern for sepsis; however, in the otherwise clincially stable patient with cancer, type B lactic acidosis can also be related to their underlying malignancy. It is considered a haematological emergency given its high mortality rate. However, despite the urgency to treat type B lactic acidosis in these circumstances, treatment options beyond treatment of the malignancy are limited, and its presence portends a poor prognosis. This case highlights our current understanding of type B lactic acidosis and an approach to lactic acidosis evaluation in the cancer patient.
摘要:
乳酸性酸中毒通常与组织灌注不足有关,并引起对缺氧或潜在低血压的关注。在癌症患者中,尤其是接受化疗的人,人们总是担心败血症;然而,在临床上稳定的癌症患者中,B型乳酸性酸中毒也可能与其潜在的恶性肿瘤有关。由于其死亡率高,因此被认为是血液学紧急情况。然而,尽管在这些情况下迫切需要治疗B型乳酸性酸中毒,恶性肿瘤治疗以外的治疗选择是有限的,它的存在预示着预后不良。该病例强调了我们目前对B型乳酸性酸中毒的理解以及对癌症患者乳酸性酸中毒的评估方法。