Abstract：
OBJECTIVE: This was a systematic review and meta-analysis of the prevalence of thromboembolic events in children and adolescents with antiphospholipid syndrome (APS).
METHODS: We searched PubMed, EMBASE and Web of Science to select relevant articles published between 1 January 2000 and 27 February 2022. We used the random-effects meta-analysis to estimate pooled point prevalence rates of thromboembolic events in studies with a minimum sample size of 30.
RESULTS: We included five studies reporting data of 336 children and adolescents with primary APS and secondary APS (SAPS). Pooled point prevalence rates of initial general thrombosis, arterial thrombosis, venous thrombosis and stroke in individuals with seropositive APS were 98.2% (95% confidence interval [CI] 87.5-100), 27.6% (95% CI 21.4-34.2), 51.1% (95% CI 38.2-63.9) and 13.4% 95% CI (6.3-22.7), respectively. Pooled point prevalence rates of initial arterial and venous thromboses in children and adolescents with SAPS were 45.7% (95% CI 21.1-71.6) and 29.2% (95% CI 14.8-46), respectively.
CONCLUSIONS: Arterio-venous thromboembolism is highly frequent in children and adolescents with SAPS. More studies using thrombotic and non-thrombotic APS classification criteria are warranted to better assess the frequency and predictors of thromboembolism in age- and ancestry-diverse pediatric populations affected by different types of APS.
METHODS: We searched PubMed, EMBASE and Web of Science to select relevant articles published between 1 January 2000 and 27 February 2022. We used the random-effects meta-analysis to estimate pooled point prevalence rates of thromboembolic events in studies with a minimum sample size of 30.
RESULTS: We included five studies reporting data of 336 children and adolescents with primary APS and secondary APS (SAPS). Pooled point prevalence rates of initial general thrombosis, arterial thrombosis, venous thrombosis and stroke in individuals with seropositive APS were 98.2% (95% confidence interval [CI] 87.5-100), 27.6% (95% CI 21.4-34.2), 51.1% (95% CI 38.2-63.9) and 13.4% 95% CI (6.3-22.7), respectively. Pooled point prevalence rates of initial arterial and venous thromboses in children and adolescents with SAPS were 45.7% (95% CI 21.1-71.6) and 29.2% (95% CI 14.8-46), respectively.
CONCLUSIONS: Arterio-venous thromboembolism is highly frequent in children and adolescents with SAPS. More studies using thrombotic and non-thrombotic APS classification criteria are warranted to better assess the frequency and predictors of thromboembolism in age- and ancestry-diverse pediatric populations affected by different types of APS.
摘要：
目的：这是一项关于抗磷脂综合征（APS）儿童和青少年血栓栓塞事件发生率的系统评价和荟萃分析。
方法：我们搜索了PubMed，EMBASE和WebofScience选择2000年1月1日至2022年2月27日发表的相关文章。我们使用随机效应荟萃分析来估计最小样本量为30的研究中血栓栓塞事件的汇总点患病率。
结果：我们纳入了五项研究，报告了336名患有原发性APS和继发性APS（SAPS）的儿童和青少年的数据。初始一般血栓形成的汇总点患病率，动脉血栓形成,APS阳性患者的静脉血栓形成和卒中发生率为98.2%(95%置信区间[CI]87.5-100),27.6%（95%CI21.4-34.2），51.1%（95%CI38.2-63.9）和13.4%95%CI（6.3-22.7），分别。SAPS儿童和青少年初始动脉和静脉血栓形成的汇总点患病率分别为45.7%（95%CI21.1-71.6）和29.2%（95%CI14.8-46），分别。
结论：动静脉血栓栓塞在患有SAPS的儿童和青少年中非常常见。有必要进行更多使用血栓性和非血栓性APS分类标准的研究，以更好地评估受不同类型APS影响的年龄和血统不同的儿科人群中血栓栓塞的频率和预测因素。
方法：我们搜索了PubMed，EMBASE和WebofScience选择2000年1月1日至2022年2月27日发表的相关文章。我们使用随机效应荟萃分析来估计最小样本量为30的研究中血栓栓塞事件的汇总点患病率。
结果：我们纳入了五项研究，报告了336名患有原发性APS和继发性APS（SAPS）的儿童和青少年的数据。初始一般血栓形成的汇总点患病率，动脉血栓形成,APS阳性患者的静脉血栓形成和卒中发生率为98.2%(95%置信区间[CI]87.5-100),27.6%（95%CI21.4-34.2），51.1%（95%CI38.2-63.9）和13.4%95%CI（6.3-22.7），分别。SAPS儿童和青少年初始动脉和静脉血栓形成的汇总点患病率分别为45.7%（95%CI21.1-71.6）和29.2%（95%CI14.8-46），分别。
结论：动静脉血栓栓塞在患有SAPS的儿童和青少年中非常常见。有必要进行更多使用血栓性和非血栓性APS分类标准的研究，以更好地评估受不同类型APS影响的年龄和血统不同的儿科人群中血栓栓塞的频率和预测因素。
