关键词: Cryptococcus neoformans Human pathogens Lytic polysaccharide monooxygenase Oxidoreductase Pseudomonas aeruginosa Vibrio cholerae

Mesh : Humans Mixed Function Oxygenases / metabolism Polysaccharides / metabolism Animals Fungi / enzymology pathogenicity

来  源:   DOI:10.1016/j.bbapap.2024.141012

Abstract:
Lytic polysaccharide monooxygenases (LPMOs) are redox enzymes widely studied for their involvement in microbial and fungal biomass degradation. The catalytic versatility of these enzymes is demonstrated by the recent discovery of LPMOs in arthropods, viruses, insects and ferns, where they fulfill diverse functions beyond biomass conversion. This mini-review puts a spotlight on a recently recognized aspect of LPMOs: their role in infectious processes in human pathogens. It discusses the occurrence and potential biological mechanisms of LPMOs associated with human pathogens and provides an outlook on future avenues in this emerging and exciting research field.
摘要:
裂解多糖单加氧酶(LPMO)是广泛研究的氧化还原酶,因其参与微生物和真菌生物质降解。最近在节肢动物中发现的LPMO证明了这些酶的催化多功能性,病毒,昆虫和蕨类植物,在那里,它们实现了生物质转化以外的多种功能。这篇小型评论将重点放在最近公认的LPMO方面:它们在人类病原体感染过程中的作用。它讨论了与人类病原体相关的LPMO的发生和潜在的生物学机制,并对这一新兴和令人兴奋的研究领域的未来途径提供了展望。
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