Abstract：
Various immune cells in the skin contribute to its function as a first line of defense against infection and disease, and the skin\'s dense innervation by pain-sensing sensory neurons protects the host against injury or damage signals. Dendritic cells (DCs) are a heterogeneous population of cells that link the innate immune response to the adaptive response by capturing, processing, and presenting antigens to promote T-cell differentiation and activation. DCs are abundant across peripheral tissues, including the skin, where they are found in the dermis and epidermis. Langerhans cells (LCs) are a DC subset located only in the epidermis; both populations of cells can migrate to lymph nodes to contribute to broad immune responses. Dermal DCs and LCs are found in close apposition with sensory nerve fibers in the skin and express neurotransmitter receptors, allowing them to communicate directly with the peripheral nervous system. Thus, neuroimmune signaling between DCs and/or LCs and sensory neurons can modulate physiologic and pathophysiologic pathways, including immune cell regulation, host defense, allergic response, homeostasis, and wound repair. Here, we summarize the latest discoveries on DC- and LC-neuron interaction with neurons while providing an overview of gaps and areas not previously explored. Understanding the interactions between these 2 defence systems may provide key insight into developing therapeutic targets for treating diseases such as psoriasis, neuropathic pain, and lupus.
摘要：
皮肤中的各种免疫细胞有助于其作为抵御感染/疾病的第一道防线的功能。而其通过疼痛感知感觉神经元的密集神经支配保护宿主免受损伤/损伤信号。树突状细胞（DC）是一种异质细胞群，通过捕获将先天免疫应答与适应性应答联系起来，processing,并呈递抗原以促进T细胞分化和活化。DC在外周组织中丰富，包括皮肤,它们在真皮和表皮中被发现。朗格汉斯细胞(LC)是仅位于表皮中的DC亚群;两种细胞群体都可以迀移到淋巴结以促进广泛的免疫应答。皮肤树突状细胞(DDCs)和LCs与皮肤中的感觉神经纤维紧密相连并表达神经递质受体,允许他们直接与周围神经系统沟通。因此，DC/LC和感觉神经元之间的神经免疫信号可以调节生理和病理生理通路，包括免疫细胞调节，主机防御,过敏反应,稳态，和伤口修复。这里,我们总结了DC-和LC-神经元与神经元相互作用的最新发现，同时概述了以前未探索的间隙和区域。了解这两个系统之间的相互作用可能为开发治疗牛皮癣等疾病的治疗靶点提供关键见解。神经性疼痛,和狼疮。
