UNASSIGNED: Investigate the association between serum Beclin 1 levels and the presence of cardiovascular valvular calcification in hemodialysis patients.
RESULTS: This study evaluated a cohort of 102 hemodialysis patients, evenly divided into two groups based on echocardiographic findings. All participants underwent serum Beclin 1 measurement and transthoracic echocardiography. Patients with acute kidney injury, active malignancy, or diabetes were excluded. Our study revealed significant differences between the two groups in terms of: Serum Beclin 1 levels, all parameters of lipid profile, prevalence of ischemic heart disease, serum albumin levels and Total calcium. Echocardiography in Group 1 showed that most cases (60.78%) exhibited mild aortic valve calcification. Additionally, significant relationships were observed between Beclin 1 and: ischemic heart disease (p=0.011) Aortic valve calcification on echocardiography (p < 0.001) Interestingly, lower Beclin 1 levels were associated with more severe valve calcification. A Beclin 1 cutoff value of ≤ 35.5 ng/ml demonstrated the highest sensitivity (98%) and specificity (92%).
CONCLUSIONS: Our findings suggest that the serum Beclin 1 level could be incorporated into a predictive model for cardiac valvular calcification in hemodialysis patients.
■研究血液透析患者血清Beclin1水平与心血管瓣膜钙化之间的关系。
结果:这项研究评估了102名血液透析患者的队列,根据超声心动图检查结果分为两组。所有参与者均接受血清Beclin1测量和经胸超声心动图检查。急性肾损伤患者,活动性恶性肿瘤,或糖尿病被排除。我们的研究揭示了两组之间在以下方面的显着差异:血清Beclin1水平,脂质分布的所有参数,缺血性心脏病的患病率,血清白蛋白水平和总钙。第1组的超声心动图显示,大多数病例(60.78%)表现为轻度主动脉瓣钙化。此外,Beclin1和:缺血性心脏病(p=0.011)主动脉瓣钙化在超声心动图(p<0.001)较低的Beclin1水平与更严重的瓣膜钙化相关。Beclin1截止值≤35.5ng/ml显示出最高的灵敏度(98%)和特异性(92%)。
结论:我们的研究结果表明,血清Beclin1水平可以纳入血液透析患者心脏瓣膜钙化的预测模型。