Abstract：
BACKGROUND: Cardiovascular calcification is a pervasive issue throughout chronic kidney disease (CKD) progression. Autophagy, a fundamental cellular process, exerts significant influence on various cardiac pathologies, including arrhythmias, atherosclerosis, heart failure, and notably, valvular, and vascular calcifications. Beclin-1, a crucial eukaryotic protein, plays a major regulatory role in autophagy as part of the phosphatidylinositol-3-kinase (PI3K) complex. Recent evidence suggests a protective role for Beclin-1-mediated autophagy in CKD vascular calcification, raising its potential as a novel therapeutic target in this context.
UNASSIGNED: Investigate the association between serum Beclin 1 levels and the presence of cardiovascular valvular calcification in hemodialysis patients.
RESULTS: This study evaluated a cohort of 102 hemodialysis patients, evenly divided into two groups based on echocardiographic findings. All participants underwent serum Beclin 1 measurement and transthoracic echocardiography. Patients with acute kidney injury, active malignancy, or diabetes were excluded. Our study revealed significant differences between the two groups in terms of: Serum Beclin 1 levels, all parameters of lipid profile, prevalence of ischemic heart disease, serum albumin levels and Total calcium. Echocardiography in Group 1 showed that most cases (60.78%) exhibited mild aortic valve calcification. Additionally, significant relationships were observed between Beclin 1 and: ischemic heart disease (p=0.011) Aortic valve calcification on echocardiography (p < 0.001) Interestingly, lower Beclin 1 levels were associated with more severe valve calcification. A Beclin 1 cutoff value of ≤ 35.5 ng/ml demonstrated the highest sensitivity (98%) and specificity (92%).
CONCLUSIONS: Our findings suggest that the serum Beclin 1 level could be incorporated into a predictive model for cardiac valvular calcification in hemodialysis patients.
UNASSIGNED: Investigate the association between serum Beclin 1 levels and the presence of cardiovascular valvular calcification in hemodialysis patients.
RESULTS: This study evaluated a cohort of 102 hemodialysis patients, evenly divided into two groups based on echocardiographic findings. All participants underwent serum Beclin 1 measurement and transthoracic echocardiography. Patients with acute kidney injury, active malignancy, or diabetes were excluded. Our study revealed significant differences between the two groups in terms of: Serum Beclin 1 levels, all parameters of lipid profile, prevalence of ischemic heart disease, serum albumin levels and Total calcium. Echocardiography in Group 1 showed that most cases (60.78%) exhibited mild aortic valve calcification. Additionally, significant relationships were observed between Beclin 1 and: ischemic heart disease (p=0.011) Aortic valve calcification on echocardiography (p < 0.001) Interestingly, lower Beclin 1 levels were associated with more severe valve calcification. A Beclin 1 cutoff value of ≤ 35.5 ng/ml demonstrated the highest sensitivity (98%) and specificity (92%).
CONCLUSIONS: Our findings suggest that the serum Beclin 1 level could be incorporated into a predictive model for cardiac valvular calcification in hemodialysis patients.
摘要：
背景：心血管钙化是慢性肾病（CKD）进展过程中普遍存在的问题。自噬,一个基本的细胞过程，对各种心脏病变产生重大影响，包括心律失常,动脉粥样硬化,心力衰竭,尤其是,瓣膜,血管钙化.Beclin-1，一种至关重要的真核蛋白质，作为磷脂酰肌醇-3-激酶（PI3K）复合物的一部分，在自噬中起主要调节作用。最近的证据表明，Beclin-1介导的自噬在CKD血管钙化中具有保护作用，在这种情况下，提高了其作为新型治疗靶标的潜力。
■研究血液透析患者血清Beclin1水平与心血管瓣膜钙化之间的关系。
结果：这项研究评估了102名血液透析患者的队列，根据超声心动图检查结果分为两组。所有参与者均接受血清Beclin1测量和经胸超声心动图检查。急性肾损伤患者,活动性恶性肿瘤，或糖尿病被排除。我们的研究揭示了两组之间在以下方面的显着差异：血清Beclin1水平，脂质分布的所有参数，缺血性心脏病的患病率，血清白蛋白水平和总钙。第1组的超声心动图显示，大多数病例（60.78％）表现为轻度主动脉瓣钙化。此外,Beclin1和：缺血性心脏病(p=0.011)主动脉瓣钙化在超声心动图(p<0.001)较低的Beclin1水平与更严重的瓣膜钙化相关。Beclin1截止值≤35.5ng/ml显示出最高的灵敏度（98％）和特异性（92％）。
结论：我们的研究结果表明，血清Beclin1水平可以纳入血液透析患者心脏瓣膜钙化的预测模型。
■研究血液透析患者血清Beclin1水平与心血管瓣膜钙化之间的关系。
结果：这项研究评估了102名血液透析患者的队列，根据超声心动图检查结果分为两组。所有参与者均接受血清Beclin1测量和经胸超声心动图检查。急性肾损伤患者,活动性恶性肿瘤，或糖尿病被排除。我们的研究揭示了两组之间在以下方面的显着差异：血清Beclin1水平，脂质分布的所有参数，缺血性心脏病的患病率，血清白蛋白水平和总钙。第1组的超声心动图显示，大多数病例（60.78％）表现为轻度主动脉瓣钙化。此外,Beclin1和：缺血性心脏病(p=0.011)主动脉瓣钙化在超声心动图(p<0.001)较低的Beclin1水平与更严重的瓣膜钙化相关。Beclin1截止值≤35.5ng/ml显示出最高的灵敏度（98％）和特异性（92％）。
结论：我们的研究结果表明，血清Beclin1水平可以纳入血液透析患者心脏瓣膜钙化的预测模型。
