Abstract：
UNASSIGNED: Fungal tissue invasion in the setting of sinonasal malignancy has been rarely described in the literature. Only a handful of studies have discussed cases of suspected chronic and acute IFS (CIFS and AIFS, respectively), having an underlying undifferentiated sinonasal carcinoma, sinonasal teratocarcinosarcoma, and NK/T-cell lymphoma.
UNASSIGNED: Here, we describe 3 cases of carcinoma mimicking IFS from a single institution.
UNASSIGNED: Each of our patients presented with sinonasal complaints as an outpatient in the setting of immunosuppression. Intranasal biopsies consistently were predominated by necrotic debris, with and without fungal elements, ultimately leading to a delay of oncologic care. The final pathologies included NK/T-cell lymphoma and SNEC. All patients were followed by radiation and chemotherapy, with 1 case of mortality.
UNASSIGNED: We aim to emphasize the importance of obtaining viable tissue as pathology specimens as the presence of necrosis with fungal elements may limit the diagnosis and ultimately delay the care of an underlying sinonasal carcinoma.
UNASSIGNED: Here, we describe 3 cases of carcinoma mimicking IFS from a single institution.
UNASSIGNED: Each of our patients presented with sinonasal complaints as an outpatient in the setting of immunosuppression. Intranasal biopsies consistently were predominated by necrotic debris, with and without fungal elements, ultimately leading to a delay of oncologic care. The final pathologies included NK/T-cell lymphoma and SNEC. All patients were followed by radiation and chemotherapy, with 1 case of mortality.
UNASSIGNED: We aim to emphasize the importance of obtaining viable tissue as pathology specimens as the presence of necrosis with fungal elements may limit the diagnosis and ultimately delay the care of an underlying sinonasal carcinoma.
摘要：
■文献中很少描述鼻窦恶性肿瘤的真菌组织侵袭。只有少数研究讨论了疑似慢性和急性IFS的病例(CIFS和AIFS，分别)，有潜在的未分化的鼻窦癌，鼻窦畸胎癌肉瘤,和NK/T细胞淋巴瘤。
■这里，我们描述了3例来自单个机构的模仿IFS的癌症。
■我们的每位患者在免疫抑制的情况下作为门诊病人出现鼻窦疾病。鼻内活检始终以坏死碎片为主，有和没有真菌元素，最终导致肿瘤治疗的延迟。最终病理包括NK/T细胞淋巴瘤和SNEC。所有患者均接受放疗和化疗,1例死亡。
■我们的目标是强调获得活组织作为病理标本的重要性，因为存在带有真菌成分的坏死可能会限制诊断并最终延迟潜在的鼻窦癌的治疗。
■这里，我们描述了3例来自单个机构的模仿IFS的癌症。
■我们的每位患者在免疫抑制的情况下作为门诊病人出现鼻窦疾病。鼻内活检始终以坏死碎片为主，有和没有真菌元素，最终导致肿瘤治疗的延迟。最终病理包括NK/T细胞淋巴瘤和SNEC。所有患者均接受放疗和化疗,1例死亡。
■我们的目标是强调获得活组织作为病理标本的重要性，因为存在带有真菌成分的坏死可能会限制诊断并最终延迟潜在的鼻窦癌的治疗。
