Abstract：
To longitudinally and cross-sectionally study the differences in the uterine artery pulsatility index (UTPI), umbilical artery pulsatility index (UAPI) and placental vascularization indices (PVIs, derived from 3-dimensional power Doppler) between normal and placental insufficiency pregnancies throughout gestation.
UTPI, UAPI and PVI were measured 6 times at 4- to 5- week intervals from 11 to 13+6 weeks-36 weeks. Preeclampsia (PE) and fetal growth restriction (FGR) were defined as placental insufficiency. Comparisons of UTPI, UAPI and PVI between normal and insufficiency groups were performed by one-way repeated measures analysis of variance.
A total of 125 women were included: monitored regularly from the first trimester to 36 weeks of gestation: 109 with normal pregnancies and 16 with placental insufficiency. Longitudinal study of the normal pregnancy group showed that UTPI and UAPI decreased significantly every 4 weeks, while PVIs increased significantly every 8 weeks until term. In the placental insufficiency group however, this decrease occurred slower at 8 weeks intervals and UTPI stabilized after 24 weeks. No significant difference was noted in PVIs throughout pregnancy. Cross-sectional study from different stages of gestation showed that UTPI was higher in the insufficiency group from 15 weeks onward and PVIs were lower after 32 weeks.
Compared to high-risk pregnancies with normal outcome, UTPI and UAPI needed a longer time to reach a significant change in those with clinical confirmation of placental insufficiency pregnancies and no significant change was found in PVI throughout gestation. UTPI was the earliest factor in detecting adverse outcome pregnancies.
UTPI, UAPI and PVI were measured 6 times at 4- to 5- week intervals from 11 to 13+6 weeks-36 weeks. Preeclampsia (PE) and fetal growth restriction (FGR) were defined as placental insufficiency. Comparisons of UTPI, UAPI and PVI between normal and insufficiency groups were performed by one-way repeated measures analysis of variance.
A total of 125 women were included: monitored regularly from the first trimester to 36 weeks of gestation: 109 with normal pregnancies and 16 with placental insufficiency. Longitudinal study of the normal pregnancy group showed that UTPI and UAPI decreased significantly every 4 weeks, while PVIs increased significantly every 8 weeks until term. In the placental insufficiency group however, this decrease occurred slower at 8 weeks intervals and UTPI stabilized after 24 weeks. No significant difference was noted in PVIs throughout pregnancy. Cross-sectional study from different stages of gestation showed that UTPI was higher in the insufficiency group from 15 weeks onward and PVIs were lower after 32 weeks.
Compared to high-risk pregnancies with normal outcome, UTPI and UAPI needed a longer time to reach a significant change in those with clinical confirmation of placental insufficiency pregnancies and no significant change was found in PVI throughout gestation. UTPI was the earliest factor in detecting adverse outcome pregnancies.
摘要：
背景：为了纵向和横截面研究子宫动脉搏动指数（UTPI）的差异，脐动脉搏动指数(UAPI)和胎盘血管化指数(PVIs，源自3维功率多普勒）在整个妊娠期正常妊娠和胎盘功能不全妊娠之间。
方法：UTPI，从11到13+6周-36周以4到5周的间隔测量UAPI和PVI6次。子痫前期（PE）和胎儿生长受限（FGR）定义为胎盘功能不全。UTPI的比较，通过单向重复测量方差分析，在正常组和不足组之间进行UAPI和PVI。
结果：共纳入125名妇女：从妊娠早期到妊娠36周定期监测：109名正常妊娠，16名胎盘功能不全。正常妊娠组的纵向研究显示UTPI和UAPI每4周明显下降,而PVIs每8周显着增加直至足月。然而，在胎盘功能不全组中，这种下降以8周间隔出现,UTPI在24周后趋于稳定.在整个怀孕期间，PVIs没有显着差异。来自妊娠不同阶段的横断面研究表明，从15周开始，功能不全组中的UTPI较高，而32周后的PVI较低。
结论：与正常结局的高危妊娠相比，UTPI和UAPI需要更长的时间才能在临床确认胎盘功能不全妊娠的患者中达到显着变化，并且在整个妊娠期间未发现PVI的显着变化。UTPI是检测不良结局妊娠的最早因素。
方法：UTPI，从11到13+6周-36周以4到5周的间隔测量UAPI和PVI6次。子痫前期（PE）和胎儿生长受限（FGR）定义为胎盘功能不全。UTPI的比较，通过单向重复测量方差分析，在正常组和不足组之间进行UAPI和PVI。
结果：共纳入125名妇女：从妊娠早期到妊娠36周定期监测：109名正常妊娠，16名胎盘功能不全。正常妊娠组的纵向研究显示UTPI和UAPI每4周明显下降,而PVIs每8周显着增加直至足月。然而，在胎盘功能不全组中，这种下降以8周间隔出现,UTPI在24周后趋于稳定.在整个怀孕期间，PVIs没有显着差异。来自妊娠不同阶段的横断面研究表明，从15周开始，功能不全组中的UTPI较高，而32周后的PVI较低。
结论：与正常结局的高危妊娠相比，UTPI和UAPI需要更长的时间才能在临床确认胎盘功能不全妊娠的患者中达到显着变化，并且在整个妊娠期间未发现PVI的显着变化。UTPI是检测不良结局妊娠的最早因素。
