Abstract：
Pruritus of lymphoma is commonly associated with both Hodgkin lymphoma (HL) and angioimmunoblastic T cell lymphoma (AITL) and critically affects the life quality of patient. Recent evidence suggests that the pruritogenic cytokines seem to play a significant role in the genesis of chronic. This study aims to investigate the cytokines associated with itching in lymphoma patients and provide the basis for potential therapeutic targets. Serum samples were collected from 60 lymphoma patients, including 47 with Hodgkin lymphoma (HL) and 13 with angioimmunoblastic T-cell lymphoma (AITL), serving as the observation group (lymphoma group, LP group, n = 60). Additionally, serum samples from 8 healthy donors (HD group, n = 8) were collected for comparison. Within the lymphoma group, patients were stratified into those with pruritus (LWP group, n = 30) and those without pruritus (LWOP group, n = 30) based on the presence of skin pruritus symptoms. Elevated levels of multiple cytokines were significantly observed in the LP group in comparison to the HD group (p < 0.01). Patients in LWP group exhibited higher serum levels of IL-31 (p < 0.001), IL-1β (P = 0.039), and IL-1α (P = 0.037) compared to LWOP group. Notably, serum IL-31 levels were higher in advanced AITL patients (stage IV) than in early AITL patients (stage I-Ⅲ, P < 0.05). In subgroup analysis, patients with pruritus in the AITL group exhibited higher serum levels of MIG and CTACK compared to HL group, whereas PDGF-BB levels were significantly lower (p < 0.05). Elevated serum levels of IL-31, IL-1β, and IL-1α are linked to lymphoma-associated pruritus. Differences in serum cytokine profiles between HL and AITL subgroups are also highlighted. These findings offer valuable insights for clinical intervention in managing lymphoma-related pruritus.
摘要：
淋巴瘤的瘙痒通常与霍奇金淋巴瘤（HL）和血管免疫母细胞T细胞淋巴瘤（AITL）有关，并严重影响患者的生活质量。最近的证据表明，致痒细胞因子似乎在慢性疾病的发生中起着重要作用。本研究旨在探讨淋巴瘤患者瘙痒相关的细胞因子，为潜在的治疗靶点提供依据。收集了60名淋巴瘤患者的血清样本，包括47例霍奇金淋巴瘤（HL）和13例血管免疫母细胞性T细胞淋巴瘤（AITL），作为观察组(淋巴瘤组，LP组,n=60)。此外,来自8名健康供体的血清样本(HD组，收集n=8)用于比较。在淋巴瘤组中，患者被分层为瘙痒患者(LWP组，n=30)和无瘙痒的(LWOP组，n=30)基于皮肤瘙痒症状的存在。与HD组相比,LP组中观察到多种细胞因子水平显著升高(p<0.01)。LWP组患者血清IL-31水平较高（p<0.001），IL-1β(P=0.039),和IL-1α(P=0.037)与LWOP组比较。值得注意的是,晚期AITL患者（IV期）的血清IL-31水平高于早期AITL患者（I-III期，P<0.05)。在亚组分析中，AITL组瘙痒患者血清MIG和CTACK水平高于HL组,而PDGF-BB水平显着降低（p<0.05）。血清IL-31、IL-1β水平升高，和IL-1α与淋巴瘤相关的瘙痒有关。还强调了HL和AITL亚组之间的血清细胞因子谱的差异。这些发现为治疗淋巴瘤相关瘙痒的临床干预提供了有价值的见解。
