Abstract：
The prevalence of antibiotic-resistant pathogenic bacteria poses a significant threat to public health and ranks among the principal causes of morbidity and mortality worldwide. Antimicrobial photodynamic therapy is an emerging therapeutic technique that has excellent potential to embark upon antibiotic resistance problems. The efficacy of this therapy hinges on the careful selection of suitable photosensitizers (PSs). Transition metal complexes, such as Ruthenium (Ru) and Iridium (Ir), are highly suitable for use as PSs because of their surface plasmonic resonance, crystal structure, optical characteristics, and photonics. These metals belong to the platinum family and exhibit similar chemical behavior due to their partially filled d-shells. Ruthenium and Iridium-based complexes generate reactive oxygen species (ROS), which interact with proteins and DNA to induce cell death. As photodynamic therapeutic agents, these complexes have been widely studied for their efficacy against cancer cells, but their potential for antibacterial activity remains largely unexplored. Our study focuses on exploring the antibacterial photodynamic effect of Ruthenium and Iridium-based complexes against both Gram-positive and Gram-negative bacteria. We aim to provide a comprehensive overview of various types of research in this area, including the structures, synthesis methods, and antibacterial photodynamic applications of these complexes. Our findings will provide valuable insights into the design, development, and modification of PSs to enhance their photodynamic therapeutic effect on bacteria, along with a clear understanding of their mechanism of action.
摘要：
抗生素抗性致病菌的流行对公共健康构成重大威胁,并且是全世界发病率和死亡率的主要原因之一。抗菌光动力疗法是一种新兴的治疗技术，具有解决抗生素耐药性问题的巨大潜力。这种疗法的功效取决于仔细选择合适的光敏剂(PS)。过渡金属配合物,如钌(Ru)和铱(Ir)，由于它们的表面等离子体共振，非常适合用作PS，晶体结构,光学特性，和光子学。这些金属属于铂家族并且由于其部分填充的d壳而表现出相似的化学行为。钌和铱基配合物产生活性氧（ROS），与蛋白质和DNA相互作用诱导细胞死亡。作为光动力治疗剂，这些复合物对癌细胞的功效已被广泛研究，但它们的抗菌活性潜力在很大程度上仍未被开发。我们的研究重点是探索钌和铱基复合物对革兰氏阳性和革兰氏阴性细菌的抗菌光动力作用。我们的目标是全面概述这方面的各种研究，包括结构，合成方法，和这些配合物的抗菌光动力应用。我们的发现将为设计提供有价值的见解，发展,并对PS进行修饰以增强其对细菌的光动力治疗效果，以及对其作用机制的清晰理解。
