Abstract：
Electrospun nanofiber membranes hold great promise as scaffolds for tissue reconstruction, mirroring the natural extracellular matrix (ECM) in their structure. However, their limited bioactive functions have hindered their effectiveness in fostering wound healing. Inorganic nanoparticles possess commendable biocompatibility, which can expedite wound healing; nevertheless, deploying them in the particle form presents challenges associated with removal or collection. To capitalize on the strengths of both components, electrospun organic/inorganic hybrid nanofibers (HNFs) have emerged as a groundbreaking solution for accelerating wound healing and maintaining stability throughout the healing process. In this review, we provide an overview of recent advancements in the utilization of HNFs for wound treatment. The review begins by elucidating various fabrication methods for hybrid nanofibers, encompassing direct electrospinning, coaxial electrospinning, and electrospinning with subsequent loading. These techniques facilitate the construction of micro-nano structures and the controlled release of inorganic ions. Subsequently, we delve into the manifold applications of HNFs in promoting the wound regeneration process. These applications encompass hemostasis, antibacterial properties, anti-inflammatory effects, stimulation of cell proliferation, and facilitation of angiogenesis. Finally, we offer insights into the prospective trends in the utilization of hybrid nanofiber-based wound dressings, charting the path forward in this dynamic field of research.
摘要：
静电纺纳米纤维膜作为组织重建的支架具有很大的前景，在其结构中反映天然细胞外基质（ECM）。然而,它们有限的生物活性功能阻碍了它们促进伤口愈合的有效性。无机纳米粒子具有良好的生物相容性，这可以加速伤口愈合；尽管如此，以粒子形式部署它们会带来与移除或收集相关的挑战。为了利用这两个组件的优势，电纺有机/无机混合纳米纤维（HNFs）已成为加速伤口愈合和在整个愈合过程中保持稳定性的开创性解决方案。在这次审查中,我们概述了HNFs用于伤口治疗的最新进展。该综述首先阐明了混合纳米纤维的各种制造方法，包括直接静电纺丝，同轴静电纺丝，和静电纺丝，随后加载。这些技巧有助于微纳米构造的构建和无机离子的可控释放。随后，我们深入研究了HNFs在促进伤口再生过程中的多种应用。这些应用包括止血，抗菌性能，抗炎作用，细胞增殖的刺激，促进血管生成。最后,我们提供了对混合纳米纤维基伤口敷料利用的未来趋势的见解，在这个充满活力的研究领域描绘前进的道路。
