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Abstract：
Chronic oral mucosal diseases (COMDs) represent a significant challenge for clinicians and patients. They are commonly associated with chronic pain and negative effects on healing and patient\'s quality of life. Regenerative medicine including the use of biological autologous blood-derived substances (e.g., platelet concentrates [PCs]), has been reported to improve healing and reduce pain in orthopedic and maxillofacial surgeries as well as chronic oral mucosal diseases. In this review, we aim to describe the different types of PCs and their applications in the management of COMDs such as lichen planus, mucositis, pemphigus vulgaris, mucous membrane pemphigoid, and plasma cell mucositis, in terms of healing potential, pain control, and quality of life. Overall, PC applications seem to enhance healing and reduce pain in patients with COMDs. However, due to the small sample size and the lack of standardized clinical trials, further research is required to support these findings.
摘要：
慢性口腔粘膜疾病（COMDs）对临床医生和患者来说是一个重大挑战。它们通常与慢性疼痛和对愈合和患者生活质量的负面影响有关。再生医学，包括使用生物自体血液衍生物质(例如，血小板浓缩物[PC])，据报道，可以改善骨科和颌面手术以及慢性口腔粘膜疾病的愈合并减轻疼痛。在这次审查中,我们的目标是描述不同类型的PC及其在COMD管理中的应用，如扁平苔藓，粘膜炎,寻常型天疱疮,粘膜类天疱疮，浆细胞粘膜炎,就治愈潜力而言，疼痛控制,和生活质量。总的来说,PC应用程序似乎可以增强COMDs患者的愈合并减轻疼痛。然而,由于样本量小，缺乏标准化的临床试验，需要进一步的研究来支持这些发现。
