PDF(Pubmed)
Abstract：
UNASSIGNED: Hypertriglyceridaemia (hTG) is associated with atherosclerotic cardiovascular disease, pancreatitis, and non-alcoholic fatty liver disease (NAFLD) in large population-based studies. The understanding of the impact of hereditary hTG and cardiometabolic disease status on the development of hTG and its associated cardiometabolic outcomes is more limited. We aimed to establish a multigenerational cohort to enable studies of the relationship between hTG, cardiometabolic disease and hereditary factors.
UNASSIGNED: The population-based observational Stockholm hyperTRIglyceridaemia REGister (STRIREG) study includes 1 460 184 index individuals who have measured plasma triglycerides in the clinical routine in Region Stockholm, Sweden, between 1 January 2000 and 31 December 2021. The laboratory measurements also included basic haematology, blood lipid panel, liver function tests, and HbA1c. Using the Swedish Multi-Generation register, 2 147 635 parents and siblings to the indexes were identified to form the complete study cohort. Laboratory data from participants were combined with data from several national registers that provided information on the cause of death, medical diagnoses, dispensed medicines, and socioeconomic factors including country of birth, education level, and marital status.
UNASSIGNED: The multi-generational longitudinal STRIREG cohort provides a unique opportunity to investigate different aspects of hTG as well as heredity for other metabolic diseases. Important outcome measures include mortality, cardiovascular mortality, major cardiovascular events, development of incident diabetes, and NAFLD. The STRIREG study will provide a deeper understanding of the impact of hereditary factors and associated cardiometabolic complications.
UNASSIGNED: The population-based observational Stockholm hyperTRIglyceridaemia REGister (STRIREG) study includes 1 460 184 index individuals who have measured plasma triglycerides in the clinical routine in Region Stockholm, Sweden, between 1 January 2000 and 31 December 2021. The laboratory measurements also included basic haematology, blood lipid panel, liver function tests, and HbA1c. Using the Swedish Multi-Generation register, 2 147 635 parents and siblings to the indexes were identified to form the complete study cohort. Laboratory data from participants were combined with data from several national registers that provided information on the cause of death, medical diagnoses, dispensed medicines, and socioeconomic factors including country of birth, education level, and marital status.
UNASSIGNED: The multi-generational longitudinal STRIREG cohort provides a unique opportunity to investigate different aspects of hTG as well as heredity for other metabolic diseases. Important outcome measures include mortality, cardiovascular mortality, major cardiovascular events, development of incident diabetes, and NAFLD. The STRIREG study will provide a deeper understanding of the impact of hereditary factors and associated cardiometabolic complications.
摘要：
■高甘油三酯血症（hTG）与动脉粥样硬化性心血管疾病有关，胰腺炎,和非酒精性脂肪性肝病（NAFLD）在大型人群为基础的研究。对遗传性hTG和心脏代谢疾病状态对hTG发展及其相关心脏代谢结果的影响的理解更为有限。我们的目标是建立一个多代队列，以便研究hTG之间的关系，心脏代谢疾病和遗传因素。
■基于人群的观察性斯德哥尔摩高甘油三酯血症REGister（STRIREG）研究包括1460184名在斯德哥尔摩地区的临床常规中测量了血浆甘油三酯的指标个体，瑞典,2000年1月1日至2021年12月31日。实验室测量还包括基础血液学，血脂面板，肝功能检查,和HbA1c。使用瑞典多代寄存器，确定了2147635名父母和兄弟姐妹，以形成完整的研究队列。参与者的实验室数据与提供死因信息的几个国家登记册的数据相结合，医学诊断,配药,和社会经济因素，包括出生国，教育水平,和婚姻状况。
■多代纵向STRIREG队列为研究hTG的不同方面以及其他代谢疾病的遗传提供了独特的机会。重要的结果指标包括死亡率，心血管死亡率，主要心血管事件，发生糖尿病的发展，和NAFLD。STRIREG研究将更深入地了解遗传因素和相关心脏代谢并发症的影响。
■基于人群的观察性斯德哥尔摩高甘油三酯血症REGister（STRIREG）研究包括1460184名在斯德哥尔摩地区的临床常规中测量了血浆甘油三酯的指标个体，瑞典,2000年1月1日至2021年12月31日。实验室测量还包括基础血液学，血脂面板，肝功能检查,和HbA1c。使用瑞典多代寄存器，确定了2147635名父母和兄弟姐妹，以形成完整的研究队列。参与者的实验室数据与提供死因信息的几个国家登记册的数据相结合，医学诊断,配药,和社会经济因素，包括出生国，教育水平,和婚姻状况。
■多代纵向STRIREG队列为研究hTG的不同方面以及其他代谢疾病的遗传提供了独特的机会。重要的结果指标包括死亡率，心血管死亡率，主要心血管事件，发生糖尿病的发展，和NAFLD。STRIREG研究将更深入地了解遗传因素和相关心脏代谢并发症的影响。
