PDF(Pubmed)
Abstract：
The skeletal system is crucial for supporting bodily functions, protecting vital organs, facilitating hematopoiesis, and storing essential minerals. Skeletal homeostasis, which includes aspects such as bone density, structural integrity, and regenerative processes, is essential for normal skeletal function. Autophagy, an intricate intracellular mechanism for degrading and recycling cellular components, plays a multifaceted role in bone metabolism. It involves sequestering cellular waste, damaged proteins, and organelles within autophagosomes, which are then degraded and recycled. Autophagy\'s impact on bone health varies depending on factors such as regulation, cell type, environmental cues, and physiological context. Despite being traditionally considered a cytoplasmic process, autophagy is subject to transcriptional and epigenetic regulation within the nucleus. However, the precise influence of epigenetic regulation, including DNA methylation, histone modifications, and non-coding RNA expression, on cellular fate remains incompletely understood. The interplay between autophagy and epigenetic modifications adds complexity to bone cell regulation. This article provides an in-depth exploration of the intricate interplay between these two regulatory paradigms, with a focus on the epigenetic control of autophagy in bone metabolism. Such an understanding enhances our knowledge of bone metabolism-related disorders and offers insights for the development of targeted therapeutic strategies.
摘要：
骨骼系统对于支持身体功能至关重要，保护重要器官，促进造血，储存必需的矿物质。骨骼稳态，包括骨密度等方面，结构完整性,和再生过程，对正常的骨骼功能至关重要。自噬,一种复杂的细胞内降解和回收细胞成分的机制，在骨代谢中起着多方面的作用。它涉及隔离细胞废物，受损的蛋白质，和自噬体内的细胞器，然后被降解和回收。自噬对骨骼健康的影响取决于调节等因素，细胞类型,环境线索，和生理背景。尽管传统上被认为是细胞质过程，自噬在细胞核内受到转录和表观遗传调控。然而,表观遗传调控的精确影响，包括DNA甲基化,组蛋白修饰，和非编码RNA表达，细胞命运仍然没有完全理解。自噬和表观遗传修饰之间的相互作用增加了骨细胞调节的复杂性。本文深入探讨了这两种监管范式之间错综复杂的相互作用,关注骨代谢中自噬的表观遗传控制。这种理解增强了我们对骨代谢相关疾病的认识，并为制定有针对性的治疗策略提供了见解。
