PDF(Pubmed)
Abstract：
In this systematic review and meta-analysis, the diagnostic performance of 68Ga-prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/CT was compared with that of 18F-DCFPyL PET for patients with suspected prostate cancer (PCa). Up to September 2023, the PubMed, Embase and Web of Science databases were thoroughly searched for relevant papers. Studies examining the diagnostic performance of 18F-DCFPyL PET and 68Ga-PSMA PET/CT in patients with suspected PCa were included in the present review. The Quality Assessment of Diagnostic Performance Studies-2 tool was used to rate the diagnostic performance of each study. The diagnostic performance of 18F-DCFPyL PET and 68Ga-PSMA PET/CT for primary PCa was examined by 13 studies included, comprising 1,178 patients. The pooled sensitivity and specificity of 18F-DCFPyL PET were 0.92 (95% CI, 0.85-0.96) and 0.59 (95% CI, 0.08-0.96), respectively. For 68Ga-PSMA PET/CT, the pooled sensitivity and specificity were 0.96 (95% CI, 0.88-0.99) and 0.71 (95% CI, 0.57-0.82), respectively. 18F-DCFPyL PET and 68Ga-PSMA PET/CT both had an area under the receiver operating characteristic curve of 0.92 (95% CI, 0.89-0.94). In addition, the Fagan nomogram revealed that the post-test probabilities for 18F-DCFPyL PET and 68Ga-PSMA PET/CT could rise to 69 and 77% when the pre-test probability was set at 50%. In conclusion, a comparable diagnostic performance for patients with suspected PCa was determined for 18F-DCFPyL PET and 68Ga-PSMA PET/CT. However, it is crucial to keep in mind that the findings of the present meta-analysis come from investigations with modest sample sizes. Therefore, more extensive research is required to obtain more solid data.
摘要：
在这篇系统综述和荟萃分析中，我们比较了68Ga-前列腺特异性膜抗原(PSMA)正电子发射断层扫描(PET)/CT与18F-DCFPyLPET对疑似前列腺癌(PCa)患者的诊断性能.截至2023年9月，PubMed，对Embase和WebofScience数据库进行了全面搜索，以查找相关论文。本综述包括研究18F-DCFPyLPET和68Ga-PSMAPET/CT在疑似PCa患者中的诊断性能。诊断性能研究的质量评估-2工具用于评价每个研究的诊断性能。纳入的13项研究检查了18F-DCFPyLPET和68Ga-PSMAPET/CT对原发性PCa的诊断性能，包括1,178名患者。18F-DCFPyLPET的合并敏感性和特异性分别为0.92（95％CI，0.85-0.96）和0.59（95％CI，0.08-0.96），分别。对于68Ga-PSMAPET/CT，合并的敏感性和特异性分别为0.96（95％CI，0.88-0.99）和0.71（95％CI，0.57-0.82），分别。18F-DCFPyLPET和68Ga-PSMAPET/CT的接受者工作特征曲线下面积均为0.92（95％CI，0.89-0.94）。此外,Fagan列线图显示,当测试前概率设定为50%时,18F-DCFPyLPET和68Ga-PSMAPET/CT的测试后概率可分别上升至69%和77%.总之,对于疑似PCa患者,我们对18F-DCFPyLPET和68Ga-PSMAPET/CT的诊断能力相当.然而,重要的是要记住,本荟萃分析的结果来自样本量适中的调查.因此,需要更广泛的研究来获得更可靠的数据。
