Abstract：
Our epithelium represents a battle ground against a variety of insults including pathogens and danger signals. It encodes multiple sensors that detect and respond to such insults, playing an essential role in maintaining and defending tissue homeostasis. One key set of defense mechanisms is our inflammasomes which drive innate immune responses including, sensing and responding to pathogen attack, through the secretion of pro-inflammatory cytokines and cell death. Identification of physiologically relevant triggers for inflammasomes has greatly influenced our ability to decipher the mechanisms behind inflammasome activation. Furthermore, identification of patient mutations within inflammasome components implicates their involvement in a range of epithelial diseases. This review will focus on exploring the roles of inflammasomes in epithelial immunity and cover: the diversity and differential expression of inflammasome sensors amongst our epithelial barriers, their ability to sense local infection and damage and the contribution of the inflammasomes to epithelial homeostasis and disease.
摘要：
我们的上皮代表了对抗各种侮辱的战场，包括病原体和危险信号。它编码了多个传感器来检测和响应这种侮辱，在维持和保护组织稳态方面发挥着重要作用。一组关键的防御机制是我们的炎性体，它驱动先天免疫反应，包括，感知和应对病原体攻击，通过分泌促炎细胞因子和细胞死亡。对炎症小体的生理相关触发因素的识别极大地影响了我们破译炎症小体激活机制的能力。此外，对患者炎症小体成分中的突变的鉴定提示其参与一系列上皮疾病.本文将重点探讨炎症小体在上皮免疫和覆盖中的作用：炎症小体传感器在上皮屏障中的多样性和差异表达，它们感知局部感染和损伤的能力，以及炎症体对上皮稳态和疾病的贡献。
