Abstract：
Concurrent cervical cancer with advanced pelvic organ prolapse is rare: there are no well-established treatment recommendations. It is hypothesized that chronic irritation, as with long-standing pelvic organ prolapse, may lead to dysplasia and human papillomavirus-independent carcinoma, which represents only 5% of cervical cancers. Two patients with complete uterine procidentia were referred to gynecologic oncology with cervical squamous cell carcinoma; both were clinically staged as International Federation of Gynaecology and Obstetrics IB3. Treatment planning was complicated by procidentia in both cases. Standard definitive treatment of locally advanced cervical cancer is radiation therapy and concurrent chemotherapy; however, the mobility and externalization of the target lesion raised concerns regarding anatomic reproducibility during radiation treatment. After multidisciplinary team discussion (gynecologic oncology, urogynecology, radiation oncology), surgical resection and co-management with gynecologic oncology and urogynecology were successfully performed for definitive management for both patients. Although rare, this case study demonstrates the importance of multidisciplinary coordination in these complex clinical scenarios.
摘要：
■并发宫颈癌伴有晚期盆腔器官脱垂的情况很少见：没有公认的治疗建议。假设慢性刺激，就像长期存在的盆腔器官脱垂一样，可能导致发育不良和人乳头瘤病毒非依赖性癌，仅占宫颈癌的5%。两名完全子宫前牙的患者被转诊为宫颈鳞状细胞癌的妇科肿瘤；两者在临床上都被定为国际妇产科联合会IB3。在这两种情况下，治疗计划都因procidentia而复杂化。局部晚期宫颈癌的标准治疗是放射治疗和同步化疗；然而，目标病变的移动性和外化引起了人们对放射治疗期间解剖可重复性的担忧.经过多学科小组讨论（妇科肿瘤学，泌尿妇科,放射肿瘤学），手术切除以及与妇科肿瘤和泌尿外科的联合管理均成功地对两名患者进行了明确的治疗.虽然罕见，本案例研究证明了多学科协调在这些复杂临床情景中的重要性.
