PDF(Pubmed)
Abstract：
In apes and humans, neutrophil to lymphocyte ratio (NLR) can be used as a predictive indicator of a variety of clinical conditions, longevity, and physiological stress. In chimpanzees specifically, NLR systematically varies with age, rearing, sex, and premature death, indicating that NLR may be a useful diagnostic tool in assessing primate health. To date, just one very recent study has investigated NLR in old world monkeys and found lower NLR in males and nursery-reared individuals, as well as a negative relationship between NLR and disease outcomes. Given that baboons are increasingly used as research models, we aimed to characterize NLR in baboons by providing descriptive data and examinations of baboon NLR heritability, and of the relationships between NLR, age, rearing, and sex in 387 olive baboons (Papio anubis) between 6 months and 19 years of age. We found that (1) mother-reared baboons had higher NLRs than nursery-reared baboons; (2) females had higher NLRs than males; and (3) there was a quadratic relationship between NLR and age, such that middle-aged individuals had the highest NLR values. We also examined NLR as a function of transport to a new facility using a subset of the data. Baboons exhibited significantly higher transport NLRs compared to routine exam NLRs. More specifically, adult baboons had higher transport NLRs than routine NLRs, whereas juveniles showed no such difference, suggesting that younger animals may experience transport stress differently than older animals. We also found that transport NLR was heritable, whereas routine NLR was not, possibly suggesting that stress responses (as indicated in NLR) have a strong genetic component. Consistent with research in humans and chimpanzees, these findings suggest that NLR varies with important biological and life history variables and that NLR may be a useful health biomarker in baboons.
摘要：
在类人猿和人类中，中性粒细胞与淋巴细胞比值(NLR)可作为多种临床状况的预测指标,长寿，和生理压力。特别是在黑猩猩中，NLR随年龄而系统地变化，饲养,性别,过早死亡,表明NLR可能是评估灵长类动物健康的有用诊断工具。迄今为止,最近的一项研究调查了旧世界猴子的NLR，发现雄性和托儿所饲养的个体的NLR较低，以及NLR与疾病结局之间的负相关。鉴于狒狒越来越多地被用作研究模型，我们的目标是通过提供描述数据和对狒狒NLR遗传力的检查来表征狒狒中的NLR，以及NLR之间的关系，年龄,饲养,和性别在6个月至19岁之间的387只橄榄狒狒（Papioanubis）。我们发现（1）母牛的NLR高于托儿所的狒狒；（2）女性的NLR高于男性；（3）NLR与年龄之间存在二次关系，中年人的NLR值最高。我们还使用数据的子集检查了NLR作为传输到新设施的函数。与常规检查NLR相比，狒狒表现出明显更高的转运NLR。更具体地说,成年狒狒的运输NLR比常规NLR高，而青少年没有表现出这种差异，这表明，年轻的动物可能会经历与年长的动物不同的运输压力。我们还发现运输NLR是可遗传的，而常规NLR不是，可能表明应激反应(如NLR所示)具有很强的遗传成分。与人类和黑猩猩的研究一致，这些研究结果表明,NLR随重要的生物学和生活史变量而变化,并且NLR可能是狒狒中有用的健康生物标志物.
