PDF(Pubmed)
Abstract：
The orbitofrontal cortex, one of the key neocortical areas in valuation and emotion, is critical for cognitive flexibility but its role in the consolidation of recently acquired information remains unclear. Here, we demonstrate orbitofrontal offline replay in the context of a place-reward association task on a maze with varying goal locations. When switches in place-reward coupling were applied, replay was enhanced relative to sessions with stable contingencies. Moreover, replay strength was positively correlated with the subsequent overnight change in behavioral performance. Interrogating relationships between orbitofrontal and hippocampal activity, we found that orbitofrontal and hippocampal replay could occur independently but became coordinated during a type of cortical state with strong spiking activity. These findings reveal a structured form of offline orbitofrontal ensemble activity that is correlated with cognitive flexibility required to adapt to changing task contingencies, and becomes associated with hippocampal replay only during a specific state of high cortical excitability.
摘要：
眶额皮质,估值和情感中的关键新皮质区域之一，对认知灵活性至关重要，但其在巩固最近获得的信息中的作用仍不清楚。这里,我们在目标位置不同的迷宫中，在位置-奖励关联任务的背景下演示了眶额离线重播。当开关到位-奖励耦合被应用时，相对于突发事件稳定的会话，重播得到了增强。此外，重放强度与随后的隔夜行为表现变化呈正相关。询问眶额叶和海马活动之间的关系，我们发现眶额叶和海马的重播可以独立发生,但在一种具有强尖峰活动的皮质状态下变得协调.这些发现揭示了离线眶额叶合奏活动的结构化形式，该活动与适应不断变化的任务突发事件所需的认知灵活性相关。并且仅在高皮质兴奋性的特定状态下与海马重放相关联。
