PDF(Pubmed)
Abstract：
UNASSIGNED: To determine demographic details, clinical profile, and underlying causes of limbal stem cell deficiency.
UNASSIGNED: Descriptive cross-sectional study.
UNASSIGNED: Patients visiting tertiary referral hospitals between January 2019 and December 2022 who satisfy the criteria for labeling limbal stem cell deficiency (LSCD) were enrolled. Parameters such as age, gender, region, duration, aetiology, and clinical features were noted. Descriptive statistics was applied. The student t-test was used.
UNASSIGNED: A total of 731 eyes of 489 patients with LSCD were included in our study, with age ranging from 5 to 85 years (35.0 ± 19.4 years). The most common presenting complaints were a decrease in vision 473 (96.7%), most of them 342 (69.7%) are having history of gradual progression (>3 months), and 245 (50.1%) have bilateral involvement of eyes. Average corneal clarity was found to be grade 1.6 ± 1.2 and average corneal superficial neovascularization was found to be 7.9 ± 4.3 quadrants. Clinically, we found LSCD of about up to 90° in 57 eyes, 90 to 180° in 71 eyes, 215 eyes with 180 to 270°, and the rest of 388 eyes were having more than 270° of LSCD involvement. Out of 489 patients, 142 (29.0%) patients were of chemical injury, 125 (25.6%) patients were of Steven Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), followed by 61 (12.5%) patients of vernal keratoconjunctivitis (VKC).
UNASSIGNED: The majority of patients were young males presented with more than 270° LSCD and vision <2/60. In our study, chemical injury was most common in unilateral LSCD and SJS/TEN in bilateral LSCD.
UNASSIGNED: Descriptive cross-sectional study.
UNASSIGNED: Patients visiting tertiary referral hospitals between January 2019 and December 2022 who satisfy the criteria for labeling limbal stem cell deficiency (LSCD) were enrolled. Parameters such as age, gender, region, duration, aetiology, and clinical features were noted. Descriptive statistics was applied. The student t-test was used.
UNASSIGNED: A total of 731 eyes of 489 patients with LSCD were included in our study, with age ranging from 5 to 85 years (35.0 ± 19.4 years). The most common presenting complaints were a decrease in vision 473 (96.7%), most of them 342 (69.7%) are having history of gradual progression (>3 months), and 245 (50.1%) have bilateral involvement of eyes. Average corneal clarity was found to be grade 1.6 ± 1.2 and average corneal superficial neovascularization was found to be 7.9 ± 4.3 quadrants. Clinically, we found LSCD of about up to 90° in 57 eyes, 90 to 180° in 71 eyes, 215 eyes with 180 to 270°, and the rest of 388 eyes were having more than 270° of LSCD involvement. Out of 489 patients, 142 (29.0%) patients were of chemical injury, 125 (25.6%) patients were of Steven Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), followed by 61 (12.5%) patients of vernal keratoconjunctivitis (VKC).
UNASSIGNED: The majority of patients were young males presented with more than 270° LSCD and vision <2/60. In our study, chemical injury was most common in unilateral LSCD and SJS/TEN in bilateral LSCD.
摘要：
■要确定人口统计详细信息，临床资料,和角膜缘干细胞缺乏的根本原因。
■描述性横断面研究。
■纳入了在2019年1月至2022年12月期间访问三级转诊医院且符合角膜缘干细胞缺乏症（LSCD）标记标准的患者。参数，如年龄，性别,区域,持续时间,病因学，并注意到临床特征。采用描述性统计。使用学生t检验。
■本研究共纳入489例LSCD患者的731只眼，年龄范围为5至85岁（35.0±19.4岁）。最常见的投诉是视力下降473（96.7％），他们中的大多数342人(69.7%)有逐渐发展的历史(>3个月)，和245（50.1%）有双侧眼睛受累。发现平均角膜透明度为1.6±1.2级,并且发现平均角膜表面新生血管形成为7.9±4.3象限。临床上,我们在57只眼睛中发现了高达90°的LSCD，71眼90到180°，215眼180到270°，其余388只眼均有超过270°的LSCD受累。在489名患者中，142例（29.0%）患者发生化学损伤，125例（25.6%）患者为StevenJohnson综合征（SJS）/中毒性表皮坏死松解症（TEN），其次是61例（12.5％）春季角膜结膜炎（VKC）患者。
■大多数患者为年轻男性，LSCD超过270°，视力<2/60。在我们的研究中,化学损伤在单侧LSCD和双侧LSCD中最常见SJS/TEN。
■描述性横断面研究。
■纳入了在2019年1月至2022年12月期间访问三级转诊医院且符合角膜缘干细胞缺乏症（LSCD）标记标准的患者。参数，如年龄，性别,区域,持续时间,病因学，并注意到临床特征。采用描述性统计。使用学生t检验。
■本研究共纳入489例LSCD患者的731只眼，年龄范围为5至85岁（35.0±19.4岁）。最常见的投诉是视力下降473（96.7％），他们中的大多数342人(69.7%)有逐渐发展的历史(>3个月)，和245（50.1%）有双侧眼睛受累。发现平均角膜透明度为1.6±1.2级,并且发现平均角膜表面新生血管形成为7.9±4.3象限。临床上,我们在57只眼睛中发现了高达90°的LSCD，71眼90到180°，215眼180到270°，其余388只眼均有超过270°的LSCD受累。在489名患者中，142例（29.0%）患者发生化学损伤，125例（25.6%）患者为StevenJohnson综合征（SJS）/中毒性表皮坏死松解症（TEN），其次是61例（12.5％）春季角膜结膜炎（VKC）患者。
■大多数患者为年轻男性，LSCD超过270°，视力<2/60。在我们的研究中,化学损伤在单侧LSCD和双侧LSCD中最常见SJS/TEN。
