PDF(Pubmed)
Abstract：
UNASSIGNED: Canine meningoencephalitis of unknown origin (MUO) is a debilitating disease associated with high mortality. The prognostic value of magnetic resonance imaging (MRI) findings for predicting survival at 12 months and long-term relapse remains uncertain.
UNASSIGNED: This was a retrospective cohort study evaluating the prognostic value of different MRI variables using multivariable logistic regression and Cox proportional hazards analysis.
UNASSIGNED: In total, 138 dogs were presumptively diagnosed with MUO. The most common location for lesions identified on MRI were the white matter tracts of the corona radiata and corpus callosum, followed by the frontal, sensorimotor and temporal cortices. Lower T2 lesion load (p = 0.006, OR = 0.942, CI = 0.902-0.983) was associated with longer survival and higher T1 post-contrast lesion load (p = 0.023, OR = 1.162, CI = 1.021-1.322) was associated with relapse.
UNASSIGNED: This study has identified prognostic factors that may help identify dogs at higher risk of death and relapse and therefore guide treatment recommendations.
UNASSIGNED: This was a retrospective cohort study evaluating the prognostic value of different MRI variables using multivariable logistic regression and Cox proportional hazards analysis.
UNASSIGNED: In total, 138 dogs were presumptively diagnosed with MUO. The most common location for lesions identified on MRI were the white matter tracts of the corona radiata and corpus callosum, followed by the frontal, sensorimotor and temporal cortices. Lower T2 lesion load (p = 0.006, OR = 0.942, CI = 0.902-0.983) was associated with longer survival and higher T1 post-contrast lesion load (p = 0.023, OR = 1.162, CI = 1.021-1.322) was associated with relapse.
UNASSIGNED: This study has identified prognostic factors that may help identify dogs at higher risk of death and relapse and therefore guide treatment recommendations.
摘要：
■未知起源的犬脑膜脑炎（MUO）是一种与高死亡率相关的使人衰弱的疾病。磁共振成像（MRI）结果预测12个月生存率和长期复发的预后价值仍不确定。
■这是一项回顾性队列研究，使用多变量逻辑回归和Cox比例风险分析评估不同MRI变量的预后价值。
■总共，138只狗被推定诊断为MUO。在MRI上确定的病变最常见的位置是放射状电晕和call体的白质束，紧随其后的是额叶，感觉运动和颞叶皮质。较低的T2病变负荷（p=0.006，OR=0.942，CI=0.902-0.983）与较长的生存期相关，而较高的T1造影后病变负荷（p=0.023，OR=1.162，CI=1.021-1.322）与复发相关。
■这项研究确定了预后因素，这些因素可能有助于识别死亡和复发风险较高的狗，从而指导治疗建议。
■这是一项回顾性队列研究，使用多变量逻辑回归和Cox比例风险分析评估不同MRI变量的预后价值。
■总共，138只狗被推定诊断为MUO。在MRI上确定的病变最常见的位置是放射状电晕和call体的白质束，紧随其后的是额叶，感觉运动和颞叶皮质。较低的T2病变负荷（p=0.006，OR=0.942，CI=0.902-0.983）与较长的生存期相关，而较高的T1造影后病变负荷（p=0.023，OR=1.162，CI=1.021-1.322）与复发相关。
■这项研究确定了预后因素，这些因素可能有助于识别死亡和复发风险较高的狗，从而指导治疗建议。
