PDF(Pubmed)
Abstract：
Outpatient parenteral antibiotic therapy (OPAT) aims to facilitate antibiotic treatment in non-hospital settings while minimizing hospitalization costs and infection risks. However, ensuring patient adherence, especially among socially disadvantaged groups like the homeless may be challenging. Studies indicate that increased dosing frequency negatively impacts adherence rates. Simplified dosing schedules and addressing transportation barriers are protective measures. Dalbavancin, a weekly oral antibiotic with an extended half-life, may offer a solution for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in patients with adherence challenges. We present a case of a homeless patient with MRSA bacteremia and osteomyelitis successfully treated with dalbavancin. Our case highlights the potential of dalbavancin\'s once-weekly dosing to improve adherence and treatment outcomes in challenging outpatient scenarios.
摘要：
门诊肠胃外抗生素治疗（OPAT）旨在促进非医院环境中的抗生素治疗，同时最大程度地减少住院费用和感染风险。然而,确保患者的依从性，尤其是像无家可归者这样的社会弱势群体可能具有挑战性。研究表明，增加给药频率对依从性产生负面影响。简化的给药时间表和解决运输障碍是保护措施。Dalbavancin,具有延长半衰期的每周口服抗生素，可能为有依从性挑战的患者提供耐甲氧西林金黄色葡萄球菌（MRSA）菌血症的解决方案。我们介绍了一例无家可归的MRSA菌血症和骨髓炎患者，该患者成功地用达巴万星治疗。我们的案例强调了dalbavancin每周一次给药在具有挑战性的门诊情况下改善依从性和治疗结果的潜力。
