PDF(Pubmed)
Abstract：
One of the most common oral carcinomas is oral squamous cell carcinoma (OSCC), bringing a heavy burden to global health. Although progresses have been made in the intervention of OSCC, 5 years survival of patients suffering from OSCC is poor like before regarding to the high invasiveness of OSCC, which causes metastasis and recurrence of the tumor. The relationship between pyroptosis and OSCC remains to be further investigated as pyroptosis in carcinomas has gained much attention. Herein, the key pyroptosis-related genes were identified according to The Cancer Genome Atlas (TCGA) dataset. Additionally, a prognostic model was constructed based upon three key genes (CTLA4, CD5, and IL12RB2) through least absolute shrinkage and selection operator (LASSO) analyses, as well as univariate and multivariate COX regression in OSCC. It was discovered that the high expression of these three genes was associated with the low-risk group. We also identified LAIR2 as a hub gene, whose expression negatively correlated with the risk score and the different immune cell infiltration. Finally, we proved that these three genes were independent prognostic factors linked to overall survival (OS), and reliable consequences could be predicted by this model. Our study revealed the relationship between pyroptosis and OSCC, providing insights into new treatment targets for preventing and treating OSCC.
摘要：
最常见的口腔癌之一是口腔鳞状细胞癌（OSCC）。给全球卫生带来沉重负担。尽管在OSCC的干预方面取得了进展，OSCC患者的5年生存率与以前一样差，因为OSCC的高侵袭性，导致肿瘤的转移和复发。由于癌中的焦亡已引起广泛关注，因此焦亡与OSCC之间的关系仍有待进一步研究。在这里，根据癌症基因组图谱(TCGA)数据集鉴定关键的焦亡相关基因.此外,通过最小绝对收缩和选择算子（LASSO）分析，基于三个关键基因（CTLA4，CD5和IL12RB2）构建了预后模型。以及OSCC中的单变量和多变量COX回归。发现这三个基因的高表达与低风险组有关。我们还确定了LAIR2为hub基因，其表达与风险评分和不同免疫细胞浸润呈负相关。最后,我们证明这三个基因是与总生存期（OS）相关的独立预后因素，这个模型可以预测可靠的后果。我们的研究揭示了焦亡与OSCC之间的关系，为预防和治疗OSCC提供新的治疗靶点。
