Abstract：
Erectile dysfunction is common among older men and has been associated with low serum 25-hydroxy vitamin D concentration. However, this association may be due to uncontrolled confounding, and there is a paucity of evidence from interventional studies. We aimed to examine the effect of vitamin D supplementation on the prevalence of erectile dysfunction, in an exploratory analysis using data from a large randomized controlled trial.
The D-Health Trial recruited Australians aged 60-84 years between January 2014 and May 2015 and randomly assigned them to supplementation with 60,000 IU of vitamin D or placebo per month for up to 5 years. Blood samples were collected annually from randomly selected participants (total N = 3943). We assessed erectile dysfunction at the end of the third year of follow-up. We used log-binomial regression to examine the effect of vitamin D on the prevalence of erectile dysfunction overall, and within sub-groups.
Of the 11,530 men enrolled, 8920 (77.4 %) completed the erectile dysfunction question and were included in the analysis. After three years of supplementation, the mean serum 25-hydroxy vitamin D concentration was 76 nmol/L (standard deviation (SD) 24.94) in the placebo group and 106 nmol/L (SD 26.76) in the vitamin D group (p < 0.0001). The prevalence of erectile dysfunction was 58.8 % and 59.0 % in the vitamin D and placebo groups, respectively (prevalence ratio 1.00, 95 % CI 0.97, 1.03); there was no evidence of an effect of vitamin D in any subgroup analyses.
Supplementing older men with vitamin D is unlikely to prevent or improve erectile dysfunction.
(ACTRN12613000743763).
The D-Health Trial recruited Australians aged 60-84 years between January 2014 and May 2015 and randomly assigned them to supplementation with 60,000 IU of vitamin D or placebo per month for up to 5 years. Blood samples were collected annually from randomly selected participants (total N = 3943). We assessed erectile dysfunction at the end of the third year of follow-up. We used log-binomial regression to examine the effect of vitamin D on the prevalence of erectile dysfunction overall, and within sub-groups.
Of the 11,530 men enrolled, 8920 (77.4 %) completed the erectile dysfunction question and were included in the analysis. After three years of supplementation, the mean serum 25-hydroxy vitamin D concentration was 76 nmol/L (standard deviation (SD) 24.94) in the placebo group and 106 nmol/L (SD 26.76) in the vitamin D group (p < 0.0001). The prevalence of erectile dysfunction was 58.8 % and 59.0 % in the vitamin D and placebo groups, respectively (prevalence ratio 1.00, 95 % CI 0.97, 1.03); there was no evidence of an effect of vitamin D in any subgroup analyses.
Supplementing older men with vitamin D is unlikely to prevent or improve erectile dysfunction.
(ACTRN12613000743763).
摘要：
目的：勃起功能障碍在老年男性中很常见，并且与低血清25-羟维生素D浓度有关。然而,这种联系可能是由于不受控制的混杂，介入研究缺乏证据。我们旨在研究补充维生素D对勃起功能障碍患病率的影响，在一项使用大型随机对照试验数据的探索性分析中.
方法：D-Health试验招募了2014年1月至2015年5月之间60-84岁的澳大利亚人，并随机分配他们每月补充60,000IU维生素D或安慰剂，为期5年。每年从随机选择的参与者收集血样(总N=3943)。我们在随访的第三年结束时评估了勃起功能障碍。我们使用对数二项回归来检验维生素D对勃起功能障碍总体患病率的影响。在分组内。
结果：在11,530名男性中，8920（77.4％）完成了勃起功能障碍问题，并纳入分析。经过三年的补充，安慰剂组的平均血清25-羟基维生素D浓度为76nmol/L(标准差(SD)24.94),维生素D组为106nmol/L(SD26.76)(p<0.0001).维生素D组和安慰剂组的勃起功能障碍患病率分别为58.8%和59.0%,(患病率比1.00,95%CI0.97,1.03);在任何亚组分析中,均无维生素D效应的证据.
结论：老年男性补充维生素D不太可能预防或改善勃起功能障碍。
背景：（ACTRN12613000743763）。
方法：D-Health试验招募了2014年1月至2015年5月之间60-84岁的澳大利亚人，并随机分配他们每月补充60,000IU维生素D或安慰剂，为期5年。每年从随机选择的参与者收集血样(总N=3943)。我们在随访的第三年结束时评估了勃起功能障碍。我们使用对数二项回归来检验维生素D对勃起功能障碍总体患病率的影响。在分组内。
结果：在11,530名男性中，8920（77.4％）完成了勃起功能障碍问题，并纳入分析。经过三年的补充，安慰剂组的平均血清25-羟基维生素D浓度为76nmol/L(标准差(SD)24.94),维生素D组为106nmol/L(SD26.76)(p<0.0001).维生素D组和安慰剂组的勃起功能障碍患病率分别为58.8%和59.0%,(患病率比1.00,95%CI0.97,1.03);在任何亚组分析中,均无维生素D效应的证据.
结论：老年男性补充维生素D不太可能预防或改善勃起功能障碍。
背景：（ACTRN12613000743763）。
