Abstract：
Malignant tumors constitute a significant category of diseases posing a severe threat to human survival and health, thereby representing one of the most challenging and pressing issues in the field of biomedical research. Due to their malignant nature, which is characterized by a high potential for metastasis, rapid dissemination, and frequent recurrence, the prevailing approach in clinical oncology involves a comprehensive treatment strategy that combines surgery with radiotherapy, chemotherapy, targeted drug therapies, and other interventions. Treatment resistance remains a major obstacle in the comprehensive management of tumors, serving as a primary cause for the failure of integrated tumor therapies and a critical factor contributing to patient relapse and mortality. The Minichromosome Maintenance (MCM) protein family comprises functional proteins closely associated with the development of resistance in tumor therapy.The influence of MCMs manifests through various pathways, encompassing modulation of DNA replication, cell cycle regulation, and DNA damage repair mechanisms. Consequently, this leads to an enhanced tolerance of tumor cells to chemotherapy, targeted drugs, and radiation. Consequently, this review explores the specific roles of the MCM family in various cancer treatment strategies. Its objective is to enhance our comprehension of resistance mechanisms in tumor therapy, thereby presenting novel targets for clinical research aimed at overcoming resistance in cancer treatment. This bears substantial clinical relevance.
摘要：
恶性肿瘤是严重威胁人类生存和健康的一类重要疾病,从而代表了生物医学研究领域中最具挑战性和紧迫的问题之一。由于它们的恶性，其特点是具有很高的转移潜力，快速传播,频繁复发，临床肿瘤学的流行方法涉及将手术与放疗相结合的综合治疗策略，化疗,靶向药物治疗，和其他干预措施。治疗耐药仍是肿瘤综合管理的主要障碍,作为肿瘤综合治疗失败的主要原因，也是导致患者复发和死亡的关键因素。微小染色体维持（MCM）蛋白家族包含与肿瘤治疗中耐药性发展密切相关的功能蛋白。MCM的影响通过各种途径表现出来，包括DNA复制的调节，细胞周期调节，和DNA损伤修复机制。因此,这导致肿瘤细胞对化疗的耐受性增强，靶向药物,和辐射。因此,这篇综述探讨了MCM家族在各种癌症治疗策略中的具体作用。其目的是提高我们对肿瘤治疗中耐药机制的理解，从而为旨在克服癌症治疗中的耐药性的临床研究提供了新的靶标。这具有实质性的临床相关性。
