OBJECTIVE: We present in this work a benchmarking study of the latest version of the Transport d\'Ions Lourds Dans l\'Aqua & Vivo (TILDA-V ) Monte Carlo track structure code, highlighting its capabilities for describing the full slowing down of α $\\alpha$ -particles in water and the energy deposited in cells by α $\\alpha$ -emitters in the context of TRT.
METHODS: We performed radiation transport simulations of α $\\alpha$ -particles (10 keV u - 1 ${\\rm u}^{-1}$ -100 MeV u - 1 ${\\rm u}^{-1}$ ) in water with TILDA-V and the Particle and Heavy Ion Transport code System (PHITS) version 3.33. We compared the predictions of each code in terms of track parameters (stopping power, range and radial dose profiles) and cellular S-values of the promising radionuclide astatine-211 ( 211 At $^{211}{\\rm At}$ ). Additional comparisons were made with available data in the literature.
RESULTS: The stopping power, range and radial dose profiles of α $\\alpha$ -particles computed with TILDA-V were in excellent agreement with other calculations and available data. Overall, minor differences with PHITS were ascribed to phase effects, that is, related to the use of interaction cross sections computed for water vapor or liquid water. However, important discrepancies were observed in the radial dose profiles of monoenergetic α $\\alpha$ -particles, for which PHITS results showed a large underestimation of the absorbed dose compared to other codes and experimental data. The cellular S-values of 211 At $^{211}{\\rm At}$ computed with TILDA-V agreed within 4% with the values predicted by PHITS and MIRDcell.
CONCLUSIONS: The validation of the TILDA-V code presented in this work opens the possibility to use it as an accurate simulation tool for investigating the interaction of α $\\alpha$ -particles in biological media down to the nanometer scale in the context of medical research. The code may help nuclear medicine physicians in their choice of α $\\alpha$ -emitters for TRT. Further research will focus on the application of TILDA-V for quantifying radioinduced damage on the deoxyribonucleic acid (DNA) molecule.
目的:我们在这项工作中提出了最新版本的Transportd\'IonsLourdsDansl\'Aqua&Vivo(TILDA-V)蒙特卡洛轨道结构代码的基准测试研究,在TRT的背景下,强调了其描述水中α$\\α$-粒子完全减慢以及α$\\α$-发射器在细胞中沉积的能量的能力。
方法:我们使用TILDA-V和粒子和重离子传输代码系统(PHITS)3.33版对水中的α$\\alpha$-粒子(10keVu-1${\rmu}^{-1}$-100MeVu-1$)进行了辐射传输模拟。我们比较了每个代码在轨道参数方面的预测(停止功率,范围和径向剂量曲线)和有希望的放射性核素astatine211的细胞S值(211At$^{211}{\\rmAt}$)。与文献中的可用数据进行了其他比较。
结果:停止力,用TILDA-V计算的α$\\α$-粒子的范围和径向剂量曲线与其他计算和可用数据非常吻合。总的来说,与PHITS的微小差异归因于相位效应,也就是说,与使用计算水蒸气或液态水的相互作用截面有关。然而,在单能α$\α$-粒子的径向剂量曲线中观察到重要的差异,与其他代码和实验数据相比,PHITS结果显示对吸收剂量的低估。用TILDA-V计算的211At$^{211}{\\rmAt}$的蜂窝S值与PHITS和MIRDcell预测的值在4%内一致。
结论:这项工作中提出的TILDA-V代码的验证为将其用作研究α$\\α$-粒子在生物介质中的相互作用的精确模拟工具提供了可能性。在医学研究的背景下,纳米尺度。该代码可能有助于核医学医生为TRT选择α$\\alpha$-发射体。进一步的研究将集中在TILDA-V用于量化对脱氧核糖核酸(DNA)分子的放射性损伤的应用上。