PDF(Pubmed)
Abstract：
Idiopathic chronic intestinal pseudo-obstruction (CIPO) is associated with intestinal inflammation and malabsorption and may cause serum vitamin D deficiency. We aimed to assess whether there is an association between idiopathic CIPO and serum levels of 25-hydroxy-vitamin D. Consecutive patients with confirmed diagnosis of idiopathic CIPO were prospectively enrolled and matched with healthy controls by gender, age, and BMI. Median serum level of 25-hydroxy-vitamin D of patients with CIPO was compared with that of healthy subjects using the Wilcoxon signed-rank test for matched samples. A total of 35 patients with CIPO and 35 matched healthy subjects were enrolled. All patients with CIPO had a 25-hydroxy-vitamin D deficiency with serum levels <12 ng/ml. The median serum level of vitamin D was significantly lower in patients with CIPO than in healthy controls (5.7 vs. 29.7 ng/ml, P < 0.0001). Serum level of vitamin D was not associated with gender ( P = 0.27), age ( P = 0.22), BMI ( P = 0.95), high (>10 000 × ml) WBC count ( P = 0.08), or high (>5 mg/l) C-reactive protein ( P = 0.87) among patients with CIPO. CIPO seems to be strongly associated with low serum levels of 25-hydroxy-vitamin D.
摘要：
特发性慢性假性肠梗阻（CIPO）与肠道炎症和吸收不良有关，并可能导致血清维生素D缺乏。我们旨在评估特发性CIPO与25-羟基维生素D的血清水平之间是否存在关联。对确诊为特发性CIPO的连续患者进行前瞻性招募，并按性别与健康对照进行匹配。年龄,BMI。使用匹配样本的Wilcoxon符号秩检验将CIPO患者的25-羟基维生素D的中位血清水平与健康受试者的中位血清水平进行比较。总共招募了35名CIPO患者和35名匹配的健康受试者。所有CIPO患者的25-羟基维生素D缺乏，血清水平<12ng/ml。CIPO患者的血清维生素D中位数水平明显低于健康对照组（5.7vs.29.7ng/ml,P<0.0001)。血清维生素D水平与性别无关(P=0.27)。年龄（P=0.22），BMI（P=0.95），白细胞计数高(>10000×ml)(P=0.08)，或高（>5mg/l）C反应蛋白（P=0.87）的患者与CIPO。CIPO似乎与25-羟基维生素D的低血清水平密切相关。
