PDF(Pubmed)
Abstract：
UNASSIGNED: Ehlers-Danlos syndrome (EDS) refers to a group of heritable connective tissue disorders (HCTDs). Clinical hallmarks of EDS include tissue fragility, joint hypermobility, and skin hyperextensibility. One of the consequences of tissue fragility is abnormal wound healing and scar formation, posing potential challenges for surgeons treating these patients. There are limited previous reports of EDS patients undergoing mastectomy and/or breast reconstruction, and none wherein the patient had diagnoses of both vascular EDS (vEDS) and classical EDS (cEDS).
UNASSIGNED: A 41-year-old female was referred to the plastic surgery clinic for breast reconstruction consultation after diagnosis of left breast lobular carcinoma in situ (LCIS). She has a past medical history of cEDS and vEDS with associated pectus carinatum, thoracic root dilation, and hypermobile joints. After shared decision making with the patient and her breast surgeon, it was decided the patient would benefit from bilateral prophylactic mastectomies with immediate 2-stage tissue expander (TE) reconstruction.
UNASSIGNED: The patient reported here had an unremarkable postoperative course. Her complications were limited to more than average bleeding during the first stage of reconstruction, which was easily managed with meticulous intraoperative hemostasis, and a small uncomplicated submuscular seroma 1week postoperative. She had no complications following TE to implant exchange and continues to heal well.
UNASSIGNED: This case report documents a case in which a patient with both cEDS and vEDS had an unremarkable surgical and postoperative course following bilateral prophylactic mastectomies with 2-stage TE reconstruction.
UNASSIGNED: A 41-year-old female was referred to the plastic surgery clinic for breast reconstruction consultation after diagnosis of left breast lobular carcinoma in situ (LCIS). She has a past medical history of cEDS and vEDS with associated pectus carinatum, thoracic root dilation, and hypermobile joints. After shared decision making with the patient and her breast surgeon, it was decided the patient would benefit from bilateral prophylactic mastectomies with immediate 2-stage tissue expander (TE) reconstruction.
UNASSIGNED: The patient reported here had an unremarkable postoperative course. Her complications were limited to more than average bleeding during the first stage of reconstruction, which was easily managed with meticulous intraoperative hemostasis, and a small uncomplicated submuscular seroma 1week postoperative. She had no complications following TE to implant exchange and continues to heal well.
UNASSIGNED: This case report documents a case in which a patient with both cEDS and vEDS had an unremarkable surgical and postoperative course following bilateral prophylactic mastectomies with 2-stage TE reconstruction.
摘要：
■Ehlers-Danlos综合征（EDS）是指一组遗传性结缔组织疾病（HCTDs）。EDS的临床特征包括组织脆性，关节过度活动,和皮肤过度扩张。组织脆性的后果之一是异常的伤口愈合和瘢痕形成，对治疗这些患者的外科医生构成潜在挑战。以前关于EDS患者接受乳房切除术和/或乳房再造的报道有限，并且没有患者同时诊断为血管EDS(vEDS)和经典EDS(cEDS)。
■一名41岁的女性在诊断为左乳腺小叶原位癌（LCIS）后，被转诊到整形外科诊所进行乳房重建咨询。她有cEDS和vEDS与相关胸骨的病史，胸根扩张，和超活动关节。在与病人和她的乳房外科医生共同做出决定后，决定患者将受益于双侧预防性乳腺切除术,并立即进行2期组织扩张器(TE)重建.
■此处报告的患者术后病程无明显变化。她的并发症仅限于重建第一阶段的平均出血，这很容易通过精心的术中止血来管理，术后1周出现了一个小的简单的肌下血清瘤。她在TE进行植入物交换后没有并发症，并且继续愈合良好。
■本病例报告记录了一例cEDS和vEDS患者在双侧预防性乳腺切除术并进行2期TE重建后，手术和术后病程无明显变化。
■一名41岁的女性在诊断为左乳腺小叶原位癌（LCIS）后，被转诊到整形外科诊所进行乳房重建咨询。她有cEDS和vEDS与相关胸骨的病史，胸根扩张，和超活动关节。在与病人和她的乳房外科医生共同做出决定后，决定患者将受益于双侧预防性乳腺切除术,并立即进行2期组织扩张器(TE)重建.
■此处报告的患者术后病程无明显变化。她的并发症仅限于重建第一阶段的平均出血，这很容易通过精心的术中止血来管理，术后1周出现了一个小的简单的肌下血清瘤。她在TE进行植入物交换后没有并发症，并且继续愈合良好。
■本病例报告记录了一例cEDS和vEDS患者在双侧预防性乳腺切除术并进行2期TE重建后，手术和术后病程无明显变化。
