PDF(Pubmed)
Abstract：
UNASSIGNED: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by a higher prevalence in male than in female participants. Recent studies have hypothesized the presence of different phenotypes in male and female participants with ASD. The present study aims to assess possible sex differences in cognitive and adaptive functioning, symptomatology of ASD, and psychopathological comorbidities in a large sample of children and adolescents with ASD.
UNASSIGNED: The study included a total of 2,146 children and adolescents diagnosed with ASD, comprising 1785 boys (mean age 7.12 ± 3.69 years) and 361 girls (mean age 6.25 ± 3.30 years). The age of the participants ranged from 1.35 to 19.05 years (mean age 9.98 ± 3.64). The study sought to include all children and adolescents diagnosed with Autism or ASD.
UNASSIGNED: Present results showed that girls with ASD had lower IQs than boys but similar adaptive functioning. The severity of symptoms of ASD was greater in boys than in girls, as were scores on psychopathological measures. With increasing age, boys with ASD showed greater impairment in social communication skills than girls and increased psychopathological comorbidities. Older girls showed fewer restricted and repetitive behaviors.
UNASSIGNED: Exploring phenotypic differences in children and adolescents with ASD fosters an understanding of subtle diagnostic facets that may go unrecognized, allowing for increasingly individualized and tailored interventions.
UNASSIGNED: The study included a total of 2,146 children and adolescents diagnosed with ASD, comprising 1785 boys (mean age 7.12 ± 3.69 years) and 361 girls (mean age 6.25 ± 3.30 years). The age of the participants ranged from 1.35 to 19.05 years (mean age 9.98 ± 3.64). The study sought to include all children and adolescents diagnosed with Autism or ASD.
UNASSIGNED: Present results showed that girls with ASD had lower IQs than boys but similar adaptive functioning. The severity of symptoms of ASD was greater in boys than in girls, as were scores on psychopathological measures. With increasing age, boys with ASD showed greater impairment in social communication skills than girls and increased psychopathological comorbidities. Older girls showed fewer restricted and repetitive behaviors.
UNASSIGNED: Exploring phenotypic differences in children and adolescents with ASD fosters an understanding of subtle diagnostic facets that may go unrecognized, allowing for increasingly individualized and tailored interventions.
摘要：
■自闭症谱系障碍（ASD）是一种神经发育障碍，其特征是男性参与者的患病率高于女性参与者。最近的研究假设男性和女性ASD参与者存在不同的表型。本研究旨在评估认知和适应功能方面可能存在的性别差异，ASD的症状学，大量ASD儿童和青少年的精神病理学合并症。
■该研究共纳入2,146名被诊断患有ASD的儿童和青少年，包括1785名男孩（平均年龄7.12±3.69岁）和361名女孩（平均年龄6.25±3.30岁）。参与者的年龄范围为1.35至19.05岁（平均年龄9.98±3.64）。该研究旨在包括所有被诊断患有自闭症或ASD的儿童和青少年。
■目前的结果表明，患有ASD的女孩的智商低于男孩，但适应性功能相似。男孩ASD症状的严重程度大于女孩，精神病理学评分也是如此。随着年龄的增长,与女孩相比,患有ASD的男孩在社交沟通能力方面表现出更大的障碍,并且精神病理学合并症增加.年龄较大的女孩表现出较少的限制和重复行为。
■探索ASD儿童和青少年的表型差异有助于理解可能无法识别的细微诊断方面，允许越来越个性化和量身定制的干预措施。
■该研究共纳入2,146名被诊断患有ASD的儿童和青少年，包括1785名男孩（平均年龄7.12±3.69岁）和361名女孩（平均年龄6.25±3.30岁）。参与者的年龄范围为1.35至19.05岁（平均年龄9.98±3.64）。该研究旨在包括所有被诊断患有自闭症或ASD的儿童和青少年。
■目前的结果表明，患有ASD的女孩的智商低于男孩，但适应性功能相似。男孩ASD症状的严重程度大于女孩，精神病理学评分也是如此。随着年龄的增长,与女孩相比,患有ASD的男孩在社交沟通能力方面表现出更大的障碍,并且精神病理学合并症增加.年龄较大的女孩表现出较少的限制和重复行为。
■探索ASD儿童和青少年的表型差异有助于理解可能无法识别的细微诊断方面，允许越来越个性化和量身定制的干预措施。
