PDF(Pubmed)
Abstract：
The prevalence of breast cancer among patients in Indonesia is significant. Indonesian individuals maintain the belief that cancer cannot be cured alone by pharmaceuticals and treatment; herbal remedies must be used in conjunction. Rhodomyrtus tomentosa, also known as Haramonting, is an indigenous Indonesian medicinal plant renowned for its copious antioxidant properties. The objective of study was to assess the impact of haramonting on breast cancer by examining the expression of various biomarker proteins associated with breast cancer. Haramonting was administered to breast cancer model mice at different doses over a period of 30 days. Subsequently, blood and breast samples were obtained for immunohistochemistry and enzyme-linked immunosorbent assays (ELISA). Authors have discovered that there has been a notable rise in the proliferation of epithelial cells in the duct lobes, resulting in the formation of ducts and lobules. Additionally, the researchers discovered that the breasts exhibited distinct clinical and histological alterations. Haramonting possesses the capacity to restore the concentrations of malondialdehyde (MDA) and superoxide dismutase (SOD) to normal levels in the blood serum of rats afflicted with cancer. The histopathological analysis of the breast tissue revealed elevated levels of Her2, IL33, EGFR, and MUC1. The authors also discovered a notable increase in the growth of epithelial cells, with two or more layers of cells reaching towards the centre of the duct. The size of the epithelial cells exhibits variability; however, this state ameliorates with the administration of a dosage of 300 mg/kgBW of this botanical specimen. This study proposes that Haramonting may be effective in treating breast cancer.
摘要：
印度尼西亚患者中乳腺癌的患病率很高。印度尼西亚人坚持认为，癌症不能单独通过药物和治疗来治愈；草药必须结合使用。番茄红景天，也被称为Haramonting，是印度尼西亚本土药用植物，以其丰富的抗氧化特性而闻名。研究的目的是通过检查与乳腺癌相关的各种生物标志物蛋白的表达来评估haramonting对乳腺癌的影响。在30天的时间内以不同剂量向乳腺癌模型小鼠施用Haramonting。随后，采集血液和乳腺样本进行免疫组织化学和酶联免疫吸附测定(ELISA).作者发现，导管叶中上皮细胞的增殖显着增加，导致导管和小叶的形成。此外,研究人员发现乳房表现出明显的临床和组织学改变。Haramonting具有将癌症大鼠血清中丙二醛（MDA）和超氧化物歧化酶（SOD）的浓度恢复到正常水平的能力。乳腺组织的组织病理学分析显示Her2、IL33、EGFR、MUC1作者还发现上皮细胞的生长显着增加，两层或多层细胞到达管道的中心。上皮细胞的大小表现出变异性；然而，通过给予该植物标本300mg/kgBW的剂量，这种状态得到改善。这项研究提出Haramonting可能对治疗乳腺癌有效。
