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Abstract：
UNASSIGNED: Our study aimed to explore the correlation between Sjögren syndrome, sociodemographic factors, comorbid conditions, and optic neuritis.
UNASSIGNED: This retrospective, nationwide, population-based, matched case-control investigation involved 33,190 individuals diagnosed with optic neuritis, identified using the International Classification of Diseases, Ninth Revision, Clinical Modification codes 377.30 for optic neuritis or 377.32 for retrobulbar neuritis. Patient data were extracted from the Taiwan National Health Insurance Research Database. Demographic characteristics, the presence of Sjögren syndrome, and pre-existing comorbid conditions were analyzed using univariate logistic regression. Continuous variables were assessed with a paired t-test. Adjusted logistic regression was employed to compare the prognosis odds ratio (OR) of patients with optic neuritis to controls.
UNASSIGNED: After adjusting for confounding variables, individuals with Sjögren syndrome exhibited a significantly higher likelihood of developing optic neuritis compared to controls (adjusted OR, 9.79; 95% confidence interval [CI], 7.28-12.98; p < 0.0001). Other conditions associated with increased odds of optic neuritis included rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, and granulomatous vasculitis (adjusted OR: 1.57, 95% CI: 1.33-1.86; adjusted OR: 2.02, 95% CI: 1.65-2.48; adjusted OR: 140.77, 95% CI: 35.02-565.85; adjusted OR: 2.38, 95% CI: 1.71-3.30; adjusted OR: 18.28, 95% CI: 2.21-151.45, respectively), as well as systemic infections such as human herpes viral infection and tuberculosis infection (adjusted OR: 1.50, 95% CI: 1.35-1.66; adjusted OR: 4.60, 95% CI: 3.81-5.56, respectively).
UNASSIGNED: Our findings strongly support the existence of an association between Sjögren syndrome, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, granulomatous vasculitis, human herpes viral infection, tuberculosis, and optic neuritis.
UNASSIGNED: This retrospective, nationwide, population-based, matched case-control investigation involved 33,190 individuals diagnosed with optic neuritis, identified using the International Classification of Diseases, Ninth Revision, Clinical Modification codes 377.30 for optic neuritis or 377.32 for retrobulbar neuritis. Patient data were extracted from the Taiwan National Health Insurance Research Database. Demographic characteristics, the presence of Sjögren syndrome, and pre-existing comorbid conditions were analyzed using univariate logistic regression. Continuous variables were assessed with a paired t-test. Adjusted logistic regression was employed to compare the prognosis odds ratio (OR) of patients with optic neuritis to controls.
UNASSIGNED: After adjusting for confounding variables, individuals with Sjögren syndrome exhibited a significantly higher likelihood of developing optic neuritis compared to controls (adjusted OR, 9.79; 95% confidence interval [CI], 7.28-12.98; p < 0.0001). Other conditions associated with increased odds of optic neuritis included rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, and granulomatous vasculitis (adjusted OR: 1.57, 95% CI: 1.33-1.86; adjusted OR: 2.02, 95% CI: 1.65-2.48; adjusted OR: 140.77, 95% CI: 35.02-565.85; adjusted OR: 2.38, 95% CI: 1.71-3.30; adjusted OR: 18.28, 95% CI: 2.21-151.45, respectively), as well as systemic infections such as human herpes viral infection and tuberculosis infection (adjusted OR: 1.50, 95% CI: 1.35-1.66; adjusted OR: 4.60, 95% CI: 3.81-5.56, respectively).
UNASSIGNED: Our findings strongly support the existence of an association between Sjögren syndrome, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, systemic lupus erythematosus, granulomatous vasculitis, human herpes viral infection, tuberculosis, and optic neuritis.
摘要：
■我们的研究旨在探讨干燥综合征，社会人口因素，合并症条件，和视神经炎.
■这次回顾展，全国范围内,以人口为基础,匹配的病例对照调查涉及33,190名诊断为视神经炎的个体，使用国际疾病分类确定，第九次修订,视神经炎的临床修改代码为377.30，球后神经炎的临床修改代码为377.32。患者数据从台湾国民健康保险研究数据库中提取。人口特征，舍格伦综合征的存在,和预先存在的共病条件使用单变量逻辑回归分析。用配对t检验评估连续变量。采用校正逻辑回归比较视神经炎患者与对照组的预后比值比（OR）。
■调整混杂变量后，与对照组相比，患有干燥综合征的个体表现出明显更高的发生视神经炎的可能性（调整后的OR，9.79；95%置信区间[CI]，7.28-12.98；p<0.0001）。与视神经炎几率增加相关的其他病症包括类风湿性关节炎，强直性脊柱炎,多发性硬化症,系统性红斑狼疮,和肉芽肿性血管炎（调整后OR：1.57，95％CI：1.33-1.86；调整后OR：2.02，95％CI：1.65-2.48；调整后OR：140.77，95％CI：35.02-565.85；调整后OR：2.38，95％CI：1.71-3.30；调整后OR：18.28，95％CI：2.21-151.45），以及全身性感染，例如人疱疹病毒感染和结核感染（校正OR：1.50，95％CI：1.35-1.66；校正OR：4.60，95％CI：3.81-5.56）。
■我们的发现强烈支持干燥综合征之间存在关联，类风湿性关节炎,强直性脊柱炎,多发性硬化症,系统性红斑狼疮,肉芽肿性血管炎,人类疱疹病毒感染，结核病,和视神经炎.
■这次回顾展，全国范围内,以人口为基础,匹配的病例对照调查涉及33,190名诊断为视神经炎的个体，使用国际疾病分类确定，第九次修订,视神经炎的临床修改代码为377.30，球后神经炎的临床修改代码为377.32。患者数据从台湾国民健康保险研究数据库中提取。人口特征，舍格伦综合征的存在,和预先存在的共病条件使用单变量逻辑回归分析。用配对t检验评估连续变量。采用校正逻辑回归比较视神经炎患者与对照组的预后比值比（OR）。
■调整混杂变量后，与对照组相比，患有干燥综合征的个体表现出明显更高的发生视神经炎的可能性（调整后的OR，9.79；95%置信区间[CI]，7.28-12.98；p<0.0001）。与视神经炎几率增加相关的其他病症包括类风湿性关节炎，强直性脊柱炎,多发性硬化症,系统性红斑狼疮,和肉芽肿性血管炎（调整后OR：1.57，95％CI：1.33-1.86；调整后OR：2.02，95％CI：1.65-2.48；调整后OR：140.77，95％CI：35.02-565.85；调整后OR：2.38，95％CI：1.71-3.30；调整后OR：18.28，95％CI：2.21-151.45），以及全身性感染，例如人疱疹病毒感染和结核感染（校正OR：1.50，95％CI：1.35-1.66；校正OR：4.60，95％CI：3.81-5.56）。
■我们的发现强烈支持干燥综合征之间存在关联，类风湿性关节炎,强直性脊柱炎,多发性硬化症,系统性红斑狼疮,肉芽肿性血管炎,人类疱疹病毒感染，结核病,和视神经炎.
