METHODS: We conducted a retrospective observational cohort study. We included all patients over 80 years old who underwent laparoscopic cholecystectomy. Survival analysis was conducted using the Kaplan‒Meier method. Cox regression analysis was implemented to determine potential factors associated with mortality at 24 months.
RESULTS: A total of 144 patients were included in the study, of whom 37 (25.69%) died at the two-year follow-up. Survival curves were compared for different ASA groups, showing a higher proportion of survivors at two years among patients classified as ASA 1-2 at 87.50% compared to ASA 3-4 at 63.75% (p = 0.001). An ASA score of 3-4 was identified as a statistically significant factor associated with mortality, indicating a higher risk (HR: 2.71, CI95%:1.20-6.14).
CONCLUSIONS: ASA 3-4 patients may benefit from conservative management due to their higher risk of mortality at 2 years and a lower probability of disease recurrence.
方法:我们进行了一项回顾性观察性队列研究。我们包括所有80岁以上接受腹腔镜胆囊切除术的患者。使用Kaplan-Meier方法进行生存分析。进行Cox回归分析以确定与24个月时死亡率相关的潜在因素。
结果:总共144名患者被纳入研究,其中37人(25.69%)在两年的随访中死亡。比较不同ASA组的生存曲线,显示在被分类为ASA1-2的患者中,两年存活的比例较高,为87.50%,而ASA3-4为63.75%(p=0.001).ASA评分3-4分被确定为与死亡率相关的统计学显著因素。表明风险较高(HR:2.71,CI95%:1.20-6.14)。
结论:ASA3-4例患者可从保守治疗中获益,因为他们2年死亡风险较高,疾病复发概率较低。