PDF(Pubmed)
Abstract：
Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedded on medical implants are surgical operations and long-term and repeated antibiotic courses. Recent years have witnessed a growing interest in the development of robust and reliable strategies for prevention and treatment of IAIs. In particular, it seems promising to develop materials with anti-biofouling and antibacterial properties for combating IAIs on implants. In this contribution, we exclusively focus on recent advances in the development of modified and functionalized implant surfaces for inhibiting bacterial attachment and eventually biofilm formation on orthopedic implants. Further, we highlight recent progress in the development of antibacterial coatings (including self-assembled nanocoatings) for preventing biofilm formation on orthopedic implants. Among the recently introduced approaches for development of efficient and durable antibacterial coatings, we focus on the use of safe and biocompatible materials with excellent antibacterial activities for local delivery of combinatorial antimicrobial agents for preventing and treating IAIs and overcoming antimicrobial resistance.
摘要：
由于生物膜的复杂结构特征及其对抗菌剂和免疫系统的固有耐受性，植入物相关感染（IAI）代表了主要的健康负担。因此，消除嵌入医疗植入物上的生物膜的可行选择是外科手术和长期和重复的抗生素疗程。近年来，人们对制定强有力和可靠的预防和治疗IAIs的战略越来越感兴趣。特别是,它似乎有希望开发具有抗生物污染和抗菌性能的材料，以对抗植入物上的IAI。在这一贡献中,我们专注于开发改性和功能化植入物表面的最新进展，以抑制细菌附着并最终在骨科植入物上形成生物膜。Further,我们重点介绍了用于预防骨科植入物生物膜形成的抗菌涂层（包括自组装纳米涂层）的最新进展。在最近推出的开发高效耐用抗菌涂料的方法中，我们专注于使用具有优异抗菌活性的安全和生物相容性材料来局部递送组合抗微生物剂，以预防和治疗IAIs并克服抗微生物耐药性。
