PDF(Pubmed)
Abstract：
As an important functional protein molecule in the human body, human annexin A5 (hAnxA5) is widely found in human cells and body fluids. hAnxA5, the smallest type of annexin, performs a variety of biological functions by reversibly and specifically binding phosphatidylserine (PS) in a calcium-dependent manner and plays an important role in many human physiological and pathological processes. The free state hAnxA5 exists in the form of monomers and usually forms a polymer in a specific self-assembly manner when exerting biological activity. This review systematically discusses the current knowledge and understanding of hAnxA5 from three perspectives: physiopathological relevance, diagnostic value, and therapeutic utility. hAnxA5 affects the occurrence and development of many physiopathological processes. Moreover, hAnxA5 can be used independently or in combination as a biomarker of physiopathological phenomena for the diagnosis of certain diseases. Importantly, based on the properties of hAnxA5, many novel drug candidates have been designed and prepared for application in actual medical practice. However, there are also some gaps and shortcomings in hAnxA5 research. This in-depth study will not only expand the understanding of structural and functional relationships but also promote the application of hAnxA5 in the field of biomedicine.
摘要：
作为人体内重要的功能性蛋白质分子,人膜联蛋白A5(hAnxA5)广泛存在于人体细胞和体液中。hAnxA5，最小的膜联蛋白，通过以钙依赖性方式可逆和特异性结合磷脂酰丝氨酸（PS）来执行多种生物学功能，并在许多人体生理和病理过程中发挥重要作用。游离态hAnxA5以单体形式存在，在发挥生物活性时通常以特定的自组装方式形成聚合物。这篇综述从三个角度系统地讨论了hAnxA5的当前知识和理解：病理生理相关性，诊断价值，和治疗效用。hAnxA5影响许多病理生理过程的发生和发展。此外，hAnxA5可独立或组合用作用于诊断某些疾病的病理生理现象的生物标志物。重要的是,基于hAnxA5的特性,已经设计并制备了许多新的候选药物以用于实际的医疗实践中。然而,hAnxA5研究也存在一些空白和不足。这项深入研究不仅将扩大对结构和功能关系的理解，还将促进hAnxA5在生物医学领域的应用。
