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Abstract：
This review focuses on the latest advancements in magnetic hydroxyapatite (mHA) nanoparticles and their potential applications in nanomedicine and regenerative medicine. mHA nanoparticles have gained significant interest over the last few years for their great potential, offering advanced multi-therapeutic strategies because of their biocompatibility, bioactivity, and unique physicochemical features, enabling on-demand activation and control. The most relevant synthetic methods to obtain magnetic apatite-based materials, either in the form of iron-doped HA nanoparticles showing intrinsic magnetic properties or composite/hybrid compounds between HA and superparamagnetic metal oxide nanoparticles, are described as highlighting structure-property correlations. Following this, this review discusses the application of various magnetic hydroxyapatite nanomaterials in bone regeneration and nanomedicine. Finally, novel perspectives are investigated with respect to the ability of mHA nanoparticles to improve nanocarriers with homogeneous structures to promote multifunctional biological applications, such as cell stimulation and instruction, antimicrobial activity, and drug release with on-demand triggering.
摘要：
本文综述了磁性羟基磷灰石（mHA）纳米颗粒的最新进展及其在纳米医学和再生医学中的潜在应用。在过去的几年中，mHA纳米颗粒因其巨大的潜力而获得了极大的兴趣，由于其生物相容性，提供先进的多种治疗策略，生物活性，和独特的物理化学特征，启用按需激活和控制。获得磁性磷灰石基材料的最相关的合成方法，以显示固有磁性的铁掺杂HA纳米颗粒或HA和超顺磁性金属氧化物纳米颗粒之间的复合/杂化化合物的形式，被描述为突出结构-性质相关性。在此之后,本文综述了各种磁性羟基磷灰石纳米材料在骨再生和纳米医学中的应用。最后,关于mHA纳米粒子改善具有均匀结构的纳米载体以促进多功能生物应用的能力，研究了新的观点。如细胞刺激和指令，抗菌活性，和按需触发的药物释放。
