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Abstract：
Periodontitis is a complex condition. Left untreated, it leads to tooth loss and the need for prosthetic treatment. The incidence of periodontitis is steadily increasing, so new methods are being sought to aid in the diagnosis of the disease. Among the methods postulated is the determination of concentrations of bioactive compounds which include extracellular matrix metalloproteinases (MMPs). These enzymes are present in various structural elements of the stomatognathic system. The most promising enzyme of this group appears to be metalloproteinase 8 (MMP-8). MMP-8 assays are performed in gingival fluid or saliva, and MMP-8 levels have been shown to be higher in patients with periodontitis compared to healthy subjects and correlated with some clinical parameters of the condition and the severity of the disease. In addition, the preliminary usefulness of this enzyme in evaluating the effectiveness of periodontal treatment and doxycycline therapy has been demonstrated. Determination of the active form of MMP-8 (aMMP-8) in oral rinse fluid using off-the-shelf assays shows the highest potential. Despite reports about aMMP-8 and promising data on the role of MMP-8 in periodontal diagnosis, a clear determination of the usefulness of this enzyme requires further research.
摘要：
牙周炎是一种复杂的疾病。未经治疗，它导致牙齿脱落和需要修复治疗。牙周炎的发病率稳步上升,因此，人们正在寻求新的方法来帮助诊断这种疾病。假定的方法之一是测定包括细胞外基质金属蛋白酶(MMPs)的生物活性化合物的浓度。这些酶存在于口颌系统的各种结构元件中。该组中最有前途的酶似乎是金属蛋白酶8(MMP-8)。MMP-8检测在龈沟液或唾液中进行，与健康受试者相比，牙周炎患者的MMP-8水平更高，并且与病情的一些临床参数和疾病的严重程度相关。此外,该酶在评估牙周治疗和多西环素治疗的有效性方面的初步作用已得到证实。使用现成测定法测定口腔冲洗液中MMP-8的活性形式(aMMP-8)显示出最高的潜力。尽管有关于aMMP-8的报道和关于MMP-8在牙周诊断中的作用的有希望的数据，这种酶的有用性的明确确定需要进一步的研究。
