Abstract:
The effect of different diet patterns on psoriasis (PSO) and psoriatic arthritis (PSA) is unknown. Τhe aim of our study was to evaluate the effectiveness of a Mediterranean diet (MD) and Ketogenic diet (KD), in patients with PSO and PSA. Twenty-six patients were randomly assigned to start either with MD or KD for a period of 8 weeks. After a 6-week washout interval, the two groups were crossed over to the other type of diet for 8 weeks. At the end of this study, MD and KD resulted in significant reduction in weight (p = 0.002, p < 0.001, respectively), in BMI (p = 0.006, p < 0.001, respectively), in waist circumference (WC) (p = 0.001, p < 0.001, respectively), in total fat mass (p = 0.007, p < 0.001, respectively), and in visceral fat (p = 0.01, p < 0.001, respectively), in comparison with baseline. After KD, patients displayed a significant reduction in the Psoriasis Area and Severity Index (PASI) (p = 0.04), Disease Activity Index of Psoriatic Arthritis (DAPSA) (p = 0.004), interleukin (IL)-6 (p = 0.047), IL-17 (p = 0.042), and IL-23 (p = 0.037), whereas no significant differences were observed in these markers after MD (p > 0.05), compared to baseline. The 22-week MD-KD diet program in patients with PSO and PSA led to beneficial results in markers of inflammation and disease activity, which were mainly attributed to KD.
摘要:
不同饮食模式对银屑病(PSO)和银屑病关节炎(PSA)的影响尚不清楚。我们研究的目的是评估地中海饮食(MD)和生酮饮食(KD)的有效性,PSO和PSA患者。26名患者被随机分配开始治疗MD或KD,为期8周。经过6周的冲洗间隔,两组交叉使用另一种饮食8周。在这项研究结束时,MD和KD导致体重显着降低(分别为p=0.002,p<0.001),在BMI中(分别为p=0.006,p<0.001),腰围(WC)(分别为p=0.001,p<0.001),在总脂肪量中(分别为p=0.007,p<0.001),和内脏脂肪(分别为p=0.01,p<0.001),与基线相比。KD之后,患者的银屑病面积和严重程度指数(PASI)显着降低(p=0.04),银屑病关节炎的疾病活动指数(DAPSA)(p=0.004),白细胞介素(IL)-6(p=0.047),IL-17(p=0.042),和IL-23(p=0.037),而这些标志物在MD后没有观察到显著差异(p>0.05),与基线相比。PSO和PSA患者的22周MD-KD饮食计划导致炎症和疾病活动标志物的有益结果,主要归因于KD。