PDF(Pubmed)
Abstract：
The effect of different diet patterns on psoriasis (PSO) and psoriatic arthritis (PSA) is unknown. Τhe aim of our study was to evaluate the effectiveness of a Mediterranean diet (MD) and Ketogenic diet (KD), in patients with PSO and PSA. Twenty-six patients were randomly assigned to start either with MD or KD for a period of 8 weeks. After a 6-week washout interval, the two groups were crossed over to the other type of diet for 8 weeks. At the end of this study, MD and KD resulted in significant reduction in weight (p = 0.002, p < 0.001, respectively), in BMI (p = 0.006, p < 0.001, respectively), in waist circumference (WC) (p = 0.001, p < 0.001, respectively), in total fat mass (p = 0.007, p < 0.001, respectively), and in visceral fat (p = 0.01, p < 0.001, respectively), in comparison with baseline. After KD, patients displayed a significant reduction in the Psoriasis Area and Severity Index (PASI) (p = 0.04), Disease Activity Index of Psoriatic Arthritis (DAPSA) (p = 0.004), interleukin (IL)-6 (p = 0.047), IL-17 (p = 0.042), and IL-23 (p = 0.037), whereas no significant differences were observed in these markers after MD (p > 0.05), compared to baseline. The 22-week MD-KD diet program in patients with PSO and PSA led to beneficial results in markers of inflammation and disease activity, which were mainly attributed to KD.
摘要：
不同饮食模式对银屑病（PSO）和银屑病关节炎（PSA）的影响尚不清楚。我们研究的目的是评估地中海饮食（MD）和生酮饮食（KD）的有效性，PSO和PSA患者。26名患者被随机分配开始治疗MD或KD，为期8周。经过6周的冲洗间隔，两组交叉使用另一种饮食8周。在这项研究结束时，MD和KD导致体重显着降低（分别为p=0.002，p<0.001），在BMI中（分别为p=0.006，p<0.001），腰围（WC）（分别为p=0.001，p<0.001），在总脂肪量中(分别为p=0.007，p<0.001)，和内脏脂肪（分别为p=0.01，p<0.001），与基线相比。KD之后,患者的银屑病面积和严重程度指数（PASI）显着降低（p=0.04），银屑病关节炎的疾病活动指数（DAPSA）（p=0.004），白细胞介素（IL）-6（p=0.047），IL-17（p=0.042），和IL-23（p=0.037），而这些标志物在MD后没有观察到显著差异(p>0.05)，与基线相比。PSO和PSA患者的22周MD-KD饮食计划导致炎症和疾病活动标志物的有益结果，主要归因于KD。
