PDF(Pubmed)
Abstract：
Cancer is one of the most significant causes of death worldwide. Despite the rapid development of modern forms of therapy, results are still unsatisfactory. The prognosis is further worsened by the ability of cancer cells to metastasize. Thus, more effective forms of therapy, such as photodynamic therapy, are constantly being developed. The photodynamic therapeutic regimen involves administering a photosensitizer that selectively accumulates in tumor cells or is present in tumor vasculature prior to irradiation with light at a wavelength corresponding to the photosensitizer absorbance, leading to the generation of reactive oxygen species. Reactive oxygen species are responsible for the direct and indirect destruction of cancer cells. Photodynamically induced local inflammation has been shown to have the ability to activate an adaptive immune system response resulting in the destruction of tumor lesions and the creation of an immune memory. This paper focuses on presenting the latest scientific reports on the specific immune response activated by photodynamic therapy. We present newly discovered mechanisms for the induction of the adaptive response by analyzing its various stages, and the possible difficulties in generating it. We also present the results of research over the past 10 years that have focused on improving the immunological efficacy of photodynamic therapy for improved cancer therapy.
摘要：
癌症是全世界最重要的死亡原因之一。尽管现代治疗形式发展迅速，结果仍然不能令人满意。预后因癌细胞转移的能力而进一步恶化。因此，更有效的治疗形式，如光动力疗法，不断发展。光动力治疗方案包括在用对应于光敏剂吸光度的波长的光照射之前施用选择性地积聚在肿瘤细胞中或存在于肿瘤脉管系统中的光敏剂。导致活性氧的产生。活性氧负责癌细胞的直接和间接破坏。已经显示光动力诱导的局部炎症具有激活适应性免疫系统应答的能力,导致肿瘤损伤的破坏和免疫记忆的产生。本文重点介绍了光动力疗法激活的特异性免疫反应的最新科学报道。我们通过分析适应性反应的各个阶段，提出了新发现的诱导机制，以及产生它的可能困难。我们还介绍了过去10年的研究结果，这些研究的重点是提高光动力疗法的免疫学功效，以改善癌症治疗。
