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Abstract：
Single Nucleotide Polymorphisms (SNPs) are the most common type of genetic variation found in an individual\'s DNA sequences. SNPs can occur in both coding and non-coding regions of the genome and can affect gene expression, protein function, and disease susceptibility. In this systematic review, we evaluate the potential of SNPs as biomarkers in the assessment of oral mucositis (OM) severity in head and neck cancer (HNC) patients treated with concomitant chemoradiation (CRT). The study selection process involved screening 66 articles from different platforms, and after removing duplicates and excluding articles that did not meet the eligibility criteria, 23 articles were included for full-text evaluation. Among them, genes from several pathways were analyzed. The DNA damage repair pathways had the highest number of genes studied. The most frequently analyzed gene was XRCC1. The proinflammatory cytokine pathways evaluated were TNF, with three articles, and NF-κB, with one article. Most included studies showed a potential association between certain SNPs and high-grade mucositis. We conclude that SNPs can be used as possible biomarkers for the assessment of OM intensity in HNC patients, and further research is needed to explore the potential of SNPs in personalized medicine for HNC treatment.
摘要：
单核苷酸多态性（SNP）是在个体DNA序列中发现的最常见的遗传变异类型。SNP可以发生在基因组的编码区和非编码区，并且可以影响基因表达。蛋白质功能，和疾病易感性。在这次系统审查中，我们评估了SNPs作为生物标志物在评估接受同步放化疗(CRT)的头颈部肿瘤(HNC)患者口腔黏膜炎(OM)严重程度方面的潜力.研究选择过程涉及筛选来自不同平台的66篇文章，删除重复项并排除不符合资格标准的文章后，包括23篇文章进行全文评估。其中,对几种途径的基因进行了分析。DNA损伤修复途径研究的基因数量最多。最常分析的基因是XRCC1。评估的促炎细胞因子途径是TNF，有三篇文章，和NF-κB,有一篇文章。大多数纳入的研究表明，某些SNP与高级别粘膜炎之间存在潜在关联。我们得出的结论是，SNP可以用作评估HNC患者OM强度的可能生物标志物。需要进一步的研究来探索SNPs在个体化药物治疗HNC中的潜力。
