PDF(Pubmed)
Abstract：
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) driven malignancy arising from the nasopharyngeal epithelium. Current treatment strategies depend on the clinical stage of the disease, including the extent of the primary tumour, the extent of nodal disease, and the presence of distant metastasis. With the close association of EBV infection with NPC development, EBV biomarkers have shown promise in predicting treatment outcomes. Among the omic technologies, RNA and miRNA signatures have been widely studied, showing promising results in the research setting to predict treatment response. The transformation of radiology images into measurable features has facilitated the use of radiomics to generate predictive models for better prognostication and treatment selection. Nonetheless, much of this work remains in the research realm, and challenges remain in clinical implementation.
摘要：
鼻咽癌（NPC）是由鼻咽上皮引起的EB病毒（EBV）驱动的恶性肿瘤。目前的治疗策略取决于疾病的临床阶段，包括原发性肿瘤的范围，淋巴结疾病的程度，和远处转移的存在。EBV感染与鼻咽癌的发生发展密切相关,EBV生物标志物在预测治疗结果方面显示出希望。在整体技术中，RNA和miRNA特征已被广泛研究，在预测治疗反应的研究环境中显示出有希望的结果。将放射学图像转换为可测量特征有助于使用放射组学来生成预测模型，以更好地预测和治疗选择。尽管如此，这项工作大部分仍在研究领域，和挑战仍然在临床实施。
