PDF(Pubmed)
Abstract：
The blood vessels of the placenta are crucial for fetal growth. Here, lower vessel density and ornithine (Orn) content were observed in placentae for low-birth-weight fetuses versus normal-birth-weight fetuses at day 75 of gestation. Furthermore, the Orn content in placentae decreased from day 75 to 110 of gestation. To investigate the role of Orn in placental angiogenesis, 48 gilts (Bama pig) were allocated into four groups. The gilts in the control group were fed a basal diet (CON group), while those in the experimental groups were fed a basal diet supplemented with 0.05% Orn (0.05% Orn group), 0.10% Orn (0.10% Orn group), and 0.15% Orn (0.15% Orn group), respectively. The results showed that 0.15% Orn and 0.10% Orn groups exhibited increased birth weight of piglets compared with the CON group. Moreover, the 0.15% Orn group was higher than the CON group in the blood vessel densities of placenta. Mechanistically, Orn facilitated placental angiogenesis by regulating vascular endothelial growth factor-A (VEGF-A). Furthermore, maternal supplementation with 0.15% Orn during gestation increased the jejunal and ileal villi height and the concentrations of colonic propionate and butyrate in suckling piglets. Collectively, these results showed that maternal supplementation with Orn promotes placental angiogenesis and improves intestinal development of suckling piglets.
摘要：
胎盘的血管对胎儿的生长至关重要。这里,在妊娠第75天，低出生体重胎儿的胎盘血管密度和鸟氨酸（Orn）含量低于正常出生体重胎儿。此外，胎盘中的Orn含量从妊娠的第75天下降到第110天。探讨Orn在胎盘血管生成中的作用,将48只小母猪(巴马猪)分为四组。对照组母猪饲喂基础饲粮(CON组),而实验组中的那些人饲喂添加0.05％Orn的基础饮食（0.05％Orn组），0.10%Orn（0.10%Orn组），和0.15%Orn（0.15%Orn组），分别。结果表明，与CON组相比，0.15％Orn和0.10％Orn组的仔猪出生体重增加。此外，0.15%Orn组胎盘血管密度高于CON组。机械上,Orn通过调节血管内皮生长因子-A（VEGF-A）促进胎盘血管生成。此外，孕妇在妊娠期间补充0.15％Orn可增加乳猪空肠和回肠绒毛高度以及结肠丙酸盐和丁酸盐的浓度。总的来说，这些结果表明，母亲补充Orn可以促进胎盘血管生成，并改善哺乳仔猪的肠道发育。
