Abstract：
Several decades of research support the involvement of transient receptor potential (TRP) channels in nociception. Despite the disappointments of early TRPV1 antagonist programs, the TRP family remains a promising therapeutic target in pain disorders. High-dose capsaicin patches are already in clinical use to relieve neuropathic pain. At present, localized injections of the side-directed TRPV1 agonist capsaicin and resiniferatoxin are undergoing clinical trials in patients with osteoarthritis and bone cancer pain. TRPA1, TRPM3, and TRPC5 channels are also of significant interest. This review discusses the role of TRP channels in human pain conditions.
摘要：
几十年的研究支持瞬时受体电位（TRP）通道参与伤害感受。尽管早期的TRPV1拮抗剂计划令人失望，TRP家族仍然是疼痛障碍的有希望的治疗靶点.高剂量辣椒素贴剂已经在临床上用于缓解神经性疼痛。目前,在骨关节炎和骨癌疼痛患者中,局部注射侧向TRPV1激动剂辣椒素和树脂毒素正在进行临床试验.TRPA1、TRPM3和TRPC5通道也非常感兴趣。这篇综述讨论了TRP通道在人类疼痛状况中的作用。
