PDF(Pubmed)
Abstract：
UNASSIGNED: Thoracocentesis is a less invasive and expensive procedure than pleural biopsy, enabling sample collection for cytological evaluation. Cell blocks prepared from these samples provide histopathological diagnoses; further, immunohistochemistry (IHC) can be performed for subtyping malignancies, guiding the clinician in choosing the appropriate treatment modality for the patient. We aimed to determine the various histological subtypes of malignancies using cell block IHC and compare the cell block and conventional cytology methods for diagnosing malignant pleural effusion.
UNASSIGNED: All pleural fluid samples from the clinically suspicious cases of malignancy collected at the Department of Pathology, Government Medical College Kottayam, India, during 18 months, except duplicate and inadequate samples, were included in this prospective observational study. IHC was performed on cell blocks that were positive for malignancy.
UNASSIGNED: This study analyzed 630 samples, of which 121 cell blocks demonstrated the presence of malignancy. Overall, 80%, 13%, and 7% of cases were negative, suspicious, and positive for malignancy based on conventional cytology, and 81%, 0%, and 19% were negative, suspicious, and positive for malignancy based on cell blocks, respectively. Among all malignancies, adenocarcinomas from the lung (56%) were the most common, followed by adenocarcinomas from the breast (6%), squamous cell carcinomas (5%), and adenocarcinomas from the ovary (3%). Cell blocks helped detect more malignancies (19%) than conventional cytology (7%), despite a moderate agreement between both methods.
UNASSIGNED: Adenocarcinomas were the most common cause of malignant pleural effusions, and the most frequent site of origin was the lungs. Cell blocks helped diagnose more malignancies than conventional cytology.
UNASSIGNED: All pleural fluid samples from the clinically suspicious cases of malignancy collected at the Department of Pathology, Government Medical College Kottayam, India, during 18 months, except duplicate and inadequate samples, were included in this prospective observational study. IHC was performed on cell blocks that were positive for malignancy.
UNASSIGNED: This study analyzed 630 samples, of which 121 cell blocks demonstrated the presence of malignancy. Overall, 80%, 13%, and 7% of cases were negative, suspicious, and positive for malignancy based on conventional cytology, and 81%, 0%, and 19% were negative, suspicious, and positive for malignancy based on cell blocks, respectively. Among all malignancies, adenocarcinomas from the lung (56%) were the most common, followed by adenocarcinomas from the breast (6%), squamous cell carcinomas (5%), and adenocarcinomas from the ovary (3%). Cell blocks helped detect more malignancies (19%) than conventional cytology (7%), despite a moderate agreement between both methods.
UNASSIGNED: Adenocarcinomas were the most common cause of malignant pleural effusions, and the most frequent site of origin was the lungs. Cell blocks helped diagnose more malignancies than conventional cytology.
摘要：
■与胸膜活检相比，胸腔穿刺术是一种侵入性较小且昂贵的手术，使样品收集细胞学评估。从这些样品制备的细胞块提供组织病理学诊断;进一步,免疫组织化学（IHC）可以进行亚型恶性肿瘤，指导临床医生为患者选择合适的治疗方式。我们旨在使用细胞块IHC确定恶性肿瘤的各种组织学亚型，并比较细胞块和常规细胞学方法诊断恶性胸腔积液。
■病理科收集的所有临床可疑恶性肿瘤的胸膜液样本，政府医学院Kottayam,印度,18个月,除了重复和不充分的样品，被纳入这项前瞻性观察性研究。对恶性肿瘤阳性的细胞块进行IHC。
■这项研究分析了630个样本，其中121个细胞块显示存在恶性肿瘤。总的来说,80%,13%,7%的病例为阴性，可疑,根据常规细胞学检查，恶性肿瘤呈阳性，81%,0%,19%为阴性，可疑,基于细胞块的恶性肿瘤呈阳性，分别。在所有恶性肿瘤中，肺腺癌（56%）是最常见的，其次是乳腺腺癌（6％），鳞状细胞癌（5%），和卵巢腺癌（3％）。细胞块有助于检测比传统细胞学（7％）更多的恶性肿瘤（19％），尽管两种方法之间有适度的协议。
■腺癌是恶性胸腔积液的最常见原因，最常见的起源是肺。与常规细胞学相比，细胞块有助于诊断更多的恶性肿瘤。
■病理科收集的所有临床可疑恶性肿瘤的胸膜液样本，政府医学院Kottayam,印度,18个月,除了重复和不充分的样品，被纳入这项前瞻性观察性研究。对恶性肿瘤阳性的细胞块进行IHC。
■这项研究分析了630个样本，其中121个细胞块显示存在恶性肿瘤。总的来说,80%,13%,7%的病例为阴性，可疑,根据常规细胞学检查，恶性肿瘤呈阳性，81%,0%,19%为阴性，可疑,基于细胞块的恶性肿瘤呈阳性，分别。在所有恶性肿瘤中，肺腺癌（56%）是最常见的，其次是乳腺腺癌（6％），鳞状细胞癌（5%），和卵巢腺癌（3％）。细胞块有助于检测比传统细胞学（7％）更多的恶性肿瘤（19％），尽管两种方法之间有适度的协议。
■腺癌是恶性胸腔积液的最常见原因，最常见的起源是肺。与常规细胞学相比，细胞块有助于诊断更多的恶性肿瘤。
