PDF(Pubmed)
Abstract：
UNASSIGNED: Early recognition and treatment of latent tuberculosis infection(LTBI) is key to tuberculosis(TB) prevention. However, the emergence of LTBI is influenced by a combination of factors, of which the role of individual immune cytokines remains controversial. The aim of this study is to explore the influencing factors of LTBI and their effects with cytokines on LTBI.
UNASSIGNED: Close contacts of tuberculosis in Urumqi City from 2021 to 2022 were selected for the study to conduct a field survey. It used logistic regression model to analyse the influencing factors of LTBI, principal component analysis to extract a composite indicators of cytokines, and structural equation modelling to explore the direct and indirect effects of cytokines and influencing factors on LTBI.
UNASSIGNED: LTBI infection rate of 33.3% among 288 TB close contacts. A multifactorial Logistic model showed that factors influencing LTBI included education, daily contact hours, eating animal liver, and drinking coffee (P<0.05); After controlling for confounding factors and extracting composite indicators of cytokines using principal component analysis, CXCL5 and IFN-γ is a protective factor for LTBI(OR=0.572, P=0.047), IL-10 and TNF-α is a risk factor for LTBI(OR=2.119, P=0.010); Structural equation modelling shows drinking coffee, eating animal liver, daily contact hours, and IL-10 and TNF-α had direct effects on LTBI and educations had indirect effects on LTBI(P<0.05).
UNASSIGNED: IL-10 and TNF-α are involved in the immune response and are directly related to LTBI. By monitoring the cytokine levels of TB close contacts and paying attention to their dietary habits and exposure, we can detect and intervene in LTBI at an early stage and control their progression to TB.
UNASSIGNED: Close contacts of tuberculosis in Urumqi City from 2021 to 2022 were selected for the study to conduct a field survey. It used logistic regression model to analyse the influencing factors of LTBI, principal component analysis to extract a composite indicators of cytokines, and structural equation modelling to explore the direct and indirect effects of cytokines and influencing factors on LTBI.
UNASSIGNED: LTBI infection rate of 33.3% among 288 TB close contacts. A multifactorial Logistic model showed that factors influencing LTBI included education, daily contact hours, eating animal liver, and drinking coffee (P<0.05); After controlling for confounding factors and extracting composite indicators of cytokines using principal component analysis, CXCL5 and IFN-γ is a protective factor for LTBI(OR=0.572, P=0.047), IL-10 and TNF-α is a risk factor for LTBI(OR=2.119, P=0.010); Structural equation modelling shows drinking coffee, eating animal liver, daily contact hours, and IL-10 and TNF-α had direct effects on LTBI and educations had indirect effects on LTBI(P<0.05).
UNASSIGNED: IL-10 and TNF-α are involved in the immune response and are directly related to LTBI. By monitoring the cytokine levels of TB close contacts and paying attention to their dietary habits and exposure, we can detect and intervene in LTBI at an early stage and control their progression to TB.
摘要：
■早期识别和治疗潜伏性结核感染（LTBI）是预防结核病（TB）的关键。然而,LTBI的出现受到多种因素的影响，其中个体免疫细胞因子的作用仍存在争议。本研究旨在探讨LTBI的影响因素及其与细胞因子对LTBI的影响。
■选择2021-2022年乌鲁木齐市结核病密切接触者为研究对象，进行实地调查。采用Logistic回归模型对LTBI的影响因素进行分析,主成分分析提取细胞因子的复合指标，和结构方程模型，探讨细胞因子及影响因素对LTBI的直接和间接影响。
■在288个TB密切接触者中，LTBI感染率为33.3%。多因素Logistic模型显示，影响LTBI的因素包括教育、每日接触小时数,吃动物的肝脏，和饮用咖啡(P<0.05);控制混杂因素后,利用主成分分析提取细胞因子的复合指标,CXCL5和IFN-γ是LTBI的保护因子(OR=0.572,P=0.047),IL-10和TNF-α是LTBI的危险因素（OR=2.119，P=0.010）；结构方程模型显示喝咖啡，吃动物的肝脏，每日接触小时数,IL-10和TNF-α对LTBI有直接影响，教育对LTBI有间接影响（P<0.05）。
■IL-10和TNF-α参与免疫反应，并与LTBI直接相关。通过监测结核病密切接触者的细胞因子水平，并关注其饮食习惯和暴露，我们可以在早期发现和干预LTBI并控制其进展为TB。
■选择2021-2022年乌鲁木齐市结核病密切接触者为研究对象，进行实地调查。采用Logistic回归模型对LTBI的影响因素进行分析,主成分分析提取细胞因子的复合指标，和结构方程模型，探讨细胞因子及影响因素对LTBI的直接和间接影响。
■在288个TB密切接触者中，LTBI感染率为33.3%。多因素Logistic模型显示，影响LTBI的因素包括教育、每日接触小时数,吃动物的肝脏，和饮用咖啡(P<0.05);控制混杂因素后,利用主成分分析提取细胞因子的复合指标,CXCL5和IFN-γ是LTBI的保护因子(OR=0.572,P=0.047),IL-10和TNF-α是LTBI的危险因素（OR=2.119，P=0.010）；结构方程模型显示喝咖啡，吃动物的肝脏，每日接触小时数,IL-10和TNF-α对LTBI有直接影响，教育对LTBI有间接影响（P<0.05）。
■IL-10和TNF-α参与免疫反应，并与LTBI直接相关。通过监测结核病密切接触者的细胞因子水平，并关注其饮食习惯和暴露，我们可以在早期发现和干预LTBI并控制其进展为TB。
