PDF(Pubmed)
Abstract：
UNASSIGNED: Arteriovenous (AV) grafts often develop severe complications of stenosis due to neointimal proliferation that occurs either at the venous anastomosis site or at the outflow receiving vein. This study compares primary patency during 12 months of follow up for a new experimental Biomodics© interpenetrating polymer network (IPN) drug-eluting graft prototype with state-of-the-art GORE® ACUSEAL (ACUSEAL) in an AV graft model in sheep.
UNASSIGNED: An end-to-end bypass from the common carotid artery to the jugularis vein was performed bilaterally in 12 sheep. The usage of ACUSEAL or the IPN, both 6.0 mm in diameter, was determined via randomization. The sheep were followed up every 4 weeks with ultrasonic duplex scanning to determine patency; the experienced observer was blinded to the randomization. One sheep died after 11 days, and the final sample accordingly consisted of 11 animals. When comparing neointimal hyperplasia after 12 months in the two grafts, Fisher\'s exact test showed a significant difference with none out of 11 in the IPN grafts and 9 out of 11 in the ACUSEAL graft (p < 0.001). However, the Biomodics© IPN exhibited severe deterioration over time.
UNASSIGNED: Almost all of the grafts occluded during the 12 months of follow up. Although the zwitterion-bounded interpenetrating drug eluting polymer network showed signs to impair neointimal hyperplasia and thrombosis, age-related degeneration hindered demonstrating a potential improvement in patency.
UNASSIGNED: An end-to-end bypass from the common carotid artery to the jugularis vein was performed bilaterally in 12 sheep. The usage of ACUSEAL or the IPN, both 6.0 mm in diameter, was determined via randomization. The sheep were followed up every 4 weeks with ultrasonic duplex scanning to determine patency; the experienced observer was blinded to the randomization. One sheep died after 11 days, and the final sample accordingly consisted of 11 animals. When comparing neointimal hyperplasia after 12 months in the two grafts, Fisher\'s exact test showed a significant difference with none out of 11 in the IPN grafts and 9 out of 11 in the ACUSEAL graft (p < 0.001). However, the Biomodics© IPN exhibited severe deterioration over time.
UNASSIGNED: Almost all of the grafts occluded during the 12 months of follow up. Although the zwitterion-bounded interpenetrating drug eluting polymer network showed signs to impair neointimal hyperplasia and thrombosis, age-related degeneration hindered demonstrating a potential improvement in patency.
摘要：
■动静脉（AV）移植物通常由于在静脉吻合部位或接受静脉流出处发生的新内膜增生而发生严重的狭窄并发症。这项研究比较了新的实验性Biomodics©互穿聚合物网络（IPN）药物洗脱移植物原型与最先进的GORE®ACUSEAL（ACUSEAL）在绵羊的AV移植物模型中的12个月随访期间的主要通畅性。
■在12只绵羊中进行了从颈总动脉到颈静脉的端到端旁路。ACUSEAL或IPN的使用，直径均为6.0毫米，通过随机化确定。每4周对绵羊进行超声双工扫描以确定通畅性。有经验的观察者对随机分组视而不见。一只羊在11天后死亡，因此,最终样品由11只动物组成。当比较两个移植物12个月后的新生内膜增生时，Fisher精确检验显示，IPN移植物11个中没有一个，ACUSEAL移植物11个中有9个（p<0.001）。然而,随着时间的推移，Biomodics©IPN表现出严重的恶化。
■在12个月的随访中，几乎所有的移植物都被阻塞。尽管两性离子结合的互穿药物洗脱聚合物网络显示出损害新生内膜增生和血栓形成的迹象，与年龄相关的变性受阻，显示出通畅性的潜在改善。
■在12只绵羊中进行了从颈总动脉到颈静脉的端到端旁路。ACUSEAL或IPN的使用，直径均为6.0毫米，通过随机化确定。每4周对绵羊进行超声双工扫描以确定通畅性。有经验的观察者对随机分组视而不见。一只羊在11天后死亡，因此,最终样品由11只动物组成。当比较两个移植物12个月后的新生内膜增生时，Fisher精确检验显示，IPN移植物11个中没有一个，ACUSEAL移植物11个中有9个（p<0.001）。然而,随着时间的推移，Biomodics©IPN表现出严重的恶化。
■在12个月的随访中，几乎所有的移植物都被阻塞。尽管两性离子结合的互穿药物洗脱聚合物网络显示出损害新生内膜增生和血栓形成的迹象，与年龄相关的变性受阻，显示出通畅性的潜在改善。
